Discriminant Analysis on Coagulation and Fibrinolytic Data Obtained During Liver Homotransplantation^[*]

Summary

Human and canine liver transplants representing two sample populations of living and dead, were studied by means of multivariate discriminant analysis using ten coagulation assays as input parameters. This procedure produced correct sample classifications at the .975 significance level in all cases. It is suggested that such a procedure, or similar procedures, may be used, when integrated within the proper information system, as an early adjunct to prognosis. It is further concluded that coagulation parameters represents, at least in part, the basis set which spans a multivariate discriminant partition space for liver transplantation.

^* Supported by the Veterans Administration.

^** Present address: Overlake Memorial Hospital, Bellevue, Washington 98004.

^*** Present address: Veterans Administration Hospital, 150 South Huntington, Boston, Massachusetts 02130.

• References

• 1 Pechet L, Groth G. G, Daloze P. N. Changes in coagulation and fibrinolysis after orthotopic canine liver transplantation. J. Lab. clin. Med. 73: 91 1969;
• 2 Groth C. G, Pechet L, Starzl T. E. Coagulation during and after orthotopic transplantation of the human liver. Arch. Surg. 98: 31 1969;
• 3 Wilks S. S. Mathematical Statistics. 573 John Wiley and Sons; New York: 1962
• 4 Anderson T. W. Introduction to Multivariate Statistical Analysis. 126 John Wiley and Sons; New York: 1958
• 5 Dixon W. J. BMD Computer Programs Manual. 185. UCLA; Los Angeles: 1964