Platelet Coagulant Activities and Retinal Vein Thrombosis

Peter N. Walsh; Richard E. Goldberg; Richard L. Tax; Larry E. Magargal

doi:10.1055/s-0038-1651475

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1977; 38(02): 0399-0406
DOI: 10.1055/s-0038-1651475

Original Article

Schattauer GmbH

Platelet Coagulant Activities and Retinal Vein Thrombosis

Peter N. Walsh

¹Specialized Center on Thrombosis Research and Department of Medicine, Temple University Health Sciences Center Philadelphia, Pennsylvania 19140* and the Vascular Unit, Retina Service Wills Eye Hospital, Philadelphia, Pennsylvania 19130, U.S.A.

,

Richard E. Goldberg

¹Specialized Center on Thrombosis Research and Department of Medicine, Temple University Health Sciences Center Philadelphia, Pennsylvania 19140* and the Vascular Unit, Retina Service Wills Eye Hospital, Philadelphia, Pennsylvania 19130, U.S.A.

,

Richard L. Tax

¹Specialized Center on Thrombosis Research and Department of Medicine, Temple University Health Sciences Center Philadelphia, Pennsylvania 19140* and the Vascular Unit, Retina Service Wills Eye Hospital, Philadelphia, Pennsylvania 19130, U.S.A.

,

Larry E. Magargal

¹Specialized Center on Thrombosis Research and Department of Medicine, Temple University Health Sciences Center Philadelphia, Pennsylvania 19140* and the Vascular Unit, Retina Service Wills Eye Hospital, Philadelphia, Pennsylvania 19130, U.S.A.

› Author Affiliations

Abstract

Summary

To determine whether platelets play a role in the pathogenesis of retinal vein occlusion (RVO), platelets and coagulation were evaluated in 28 patients with RVO. Platelet coagulant activities concerned with the initiation and early stages of intrinsic coagulation were 2–4 fold increased in 9 patients with acute primary RVO but not in patients with acute secondary (10 patients) or chronic (9 patients) RVO. Platelet factor 3 activity, platelet aggregation, serotonin release by platelets and plasma coagulation were normal in all patients. Platelets may provide a trigger mechanism for venous thrombosis in the eye when local conditions permit.

Full Text

References

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