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Thromb Haemost 1993; 69(03): 276-281
DOI: 10.1055/s-0038-1651595
Original Article
Platelets
Schattauer GmbH Stuttgart

Effect of the Infusion of OKY-046, a Thromboxane A2 Synthase Inhibitor, on Urinary Metabolites of Prostacyclin and Thromboxane A2 in Healthy Human Subjects

H Morio
The Second Department of Internal Medicine, Chiba University Medical School, Chiba, Japan
,
A Hirai
The Second Department of Internal Medicine, Chiba University Medical School, Chiba, Japan
,
T Terano
The Second Department of Internal Medicine, Chiba University Medical School, Chiba, Japan
,
Y Tamura
The Second Department of Internal Medicine, Chiba University Medical School, Chiba, Japan
,
S Yoshida
The Second Department of Internal Medicine, Chiba University Medical School, Chiba, Japan
› Author Affiliations
Further Information

Publication History

Received 07 August 1992

Accepted after revision 09 November 1992

Publication Date:
05 July 2018 (online)

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Summary

The influence of OKY-046, a selective thromboxane synthase inhibitor, on prostanoid formation in healthy human subjects was studied. Vehicle (5% glucose solution) or OKY-046 in 5% glucose solution at 15 μg kg−1 min−1 was intravenously administered to five male healthy volunteers for 6 h. Platelet aggregation and thromboxane B2 (TXB2) formation induced by collagen and arachidonic acid were suppressed by the infusion of OKY-046, while both were not affected by the infusion of vehicle. Urinary excretion of 11-dehydro-thromboxane B2, one of major urinary metabolites of thromboxane A2 (TXA2) was decreased by the infusion of OKY-046, while that of 2,3-dinor-6-keto-prostaglandin F1α, one of major urinary metabolites of prostacyclin (PGI2) was increased. The present study demonstrated that the infusion of OKY-046 improved the balance of TXA2/PGI2 into antithrombotic state in healthy subjects. It was also suggested that endogenously produced (probably platelet-derived) endoperoxides could be redirected into prostacyclin in vivo.

 

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