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Thromb Haemost 1993; 69(04): 306-310
DOI: 10.1055/s-0038-1651602
Original Article
Clinical Studies
Schattauer GmbH Stuttgart

The Course of Preexistent Immune Abnormalities in HIV Negative Haemophiliacs Treated for Two Years with a Monoclonal Purified Factor VIII Concentrate

W M Smid
The Department of Haematology, Division of Haemostasis, Thrombosis, and Rheology, University Hospital Groningen, The Netherlands
,
J van der Meer
The Department of Haematology, Division of Haemostasis, Thrombosis, and Rheology, University Hospital Groningen, The Netherlands
,
J W Smit
The Department of Haematology, Division of Haemostasis, Thrombosis, and Rheology, University Hospital Groningen, The Netherlands
,
M R Halie
The Department of Haematology, Division of Haemostasis, Thrombosis, and Rheology, University Hospital Groningen, The Netherlands
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Publikationsverlauf

Received 05. Juni 1992

Accepted after revision 01. Dezember 1992

Publikationsdatum:
05. Juli 2018 (online)

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Summary

The administration of factor VIII concentrates has been associated with immune abnormalities in patients with severe haemophilia A, even in the absence of HIV infection.

The effects of a monoclonal purified factor VIII concentrate, Hemofil M (Baxter), on preexistent immune abnormalities were assessed over a 2 year period in 22 HIV negative haemophiliacs. They were treated previously with other concentrates, and received Hemofil T from 1983 to 1988. No HIV infection was demonstrated. No serologic evidence for other viral (re)-infections was seen. A decrease of HLA-DR expression on non-B lymphocytes in the first year (P = 0.026), and a decrease of T4-T8 ratio over the 2 years were found (P = 0.0016). Skin tests were non-contributive. The decrease in HLA-DR expression is suggestive for an improved immune function, possibly due to a reduced content of protein or virus in this concentrate.

 

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