Megakaryocytes in the Giant Platelet Syndrome

Lawrence Kass; David A. Leichtman; Theodore F. Beals; Bertram Schnitzer

doi:10.1055/s-0038-1651880

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1977; 38(03): 0652-0659
DOI: 10.1055/s-0038-1651880

Original Article

Schattauer GmbH

Megakaryocytes in the Giant Platelet Syndrome

A Cytochemical and Ultrastructural Study

Lawrence Kass

¹Department of Internal Medicine (Simpson Memorial Institute), the Department of Pathology, the University of Michigan and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan 48109, U.S.A.

,

David A. Leichtman

¹Department of Internal Medicine (Simpson Memorial Institute), the Department of Pathology, the University of Michigan and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan 48109, U.S.A.

,

Theodore F. Beals

¹Department of Internal Medicine (Simpson Memorial Institute), the Department of Pathology, the University of Michigan and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan 48109, U.S.A.

,

Bertram Schnitzer

¹Department of Internal Medicine (Simpson Memorial Institute), the Department of Pathology, the University of Michigan and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan 48109, U.S.A.

› Author Affiliations

Abstract

Summary

When compared to normal megakaryocytes, those from a patient with the giant platelet syndrome exhibited numerous cytochemical abnormalities. These reflected disturbances in the metabolism of RNA, glycogen, arginine-rich histone, and various glycolytic enzymes. Ultrastructural studies of the abnormal megakaryocytes also showed decreased glycogen and RNA (ribosomes) as well as aberrations of nuclear lobulation.

Full Text

References

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