Megakaryocytes in the Giant Platelet Syndrome

Lawrence Kass; David A. Leichtman; Theodore F. Beals; Bertram Schnitzer

doi:10.1055/s-0038-1651880

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1977; 38(03): 0652-0659
DOI: 10.1055/s-0038-1651880

Original Article

Schattauer GmbH

Megakaryocytes in the Giant Platelet Syndrome

A Cytochemical and Ultrastructural Study

Authors

Lawrence Kass

¹Department of Internal Medicine (Simpson Memorial Institute), the Department of Pathology, the University of Michigan and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan 48109, U.S.A.
David A. Leichtman

¹Department of Internal Medicine (Simpson Memorial Institute), the Department of Pathology, the University of Michigan and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan 48109, U.S.A.
Theodore F. Beals

¹Department of Internal Medicine (Simpson Memorial Institute), the Department of Pathology, the University of Michigan and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan 48109, U.S.A.
Bertram Schnitzer

¹Department of Internal Medicine (Simpson Memorial Institute), the Department of Pathology, the University of Michigan and the Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan 48109, U.S.A.

Abstract

Summary

When compared to normal megakaryocytes, those from a patient with the giant platelet syndrome exhibited numerous cytochemical abnormalities. These reflected disturbances in the metabolism of RNA, glycogen, arginine-rich histone, and various glycolytic enzymes. Ultrastructural studies of the abnormal megakaryocytes also showed decreased glycogen and RNA (ribosomes) as well as aberrations of nuclear lobulation.

Full Text

References

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