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Thromb Haemost 1977; 38(03): 0668-0676
DOI: 10.1055/s-0038-1651882
Original Article
Schattauer GmbH

Fibrinogen, Fibrinogen Degradation Products and Erythrocyte Flexibility

Michael W. Rampling
1   Department of Biophysics, St. Mary’s Hospital Medical School, Paddington, London, W. 2, England
,
John A. Sirs
1   Department of Biophysics, St. Mary’s Hospital Medical School, Paddington, London, W. 2, England
› Author Affiliations
Further Information

Publication History

Received 14 February 1977

Accepted 02 June 1977

Publication Date:
04 July 2018 (online)

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Summary

An investigation has been made of the effect of fibrinogen concentration and fibrinogen degradation products on the flexibility of erythrocytes. The measurements were made using the blood of 2 donors, one representative of the normal population, the other representative of the 1. 5% of the normal population whose flexibility is more than three standard deviations from the total population mean. A linear relationship between erythrocyte flexibility and fibrinogen concentration was found in both cases. However, while the normal control had only a slow packing rate at zero fibrinogen concentration, the fast-packing cells retained a high degree of flexibility. Digestion of fibrinogen for sufficient time to form the larger degradation fragments X and Y indicated that they have similar effects to the native fibrinogen. The smaller fragments D and E, do not affect the flexibility nor do they inhibit or modify the effect of fibrinogen.

 

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