Download PDF
Thromb Haemost 1977; 38(04): 0924-0938
DOI: 10.1055/s-0038-1651911
Original Article
Schattauer GmbH

Proteins Secreted by the Platelet

Stefan Niewiarowski
1   Specialized Center for Thrombosis Research, Department of Medicine and Physiology, Temple University Health Sciences Center, Philadelphia, Pennsylvania, 19140, U.S.A.
› Author Affiliations
Further Information

Publication History

Publication Date:
04 July 2018 (online)

Also available at
    Permissions and Reprints

 

 

  • References

  • 1 Agam G, Bessler H, Djaldetti M. 1976; In vitro DNA and RNA synthesis by human platelets. Biochimica et biophysica acta 425: 41.
    CrossrefPubMedGoogle Scholar
  • 2 Antoniades H. N, Stathakos D, Scher C. D. 1975; Isolation of a cationic polypeptide from human serum that stimulates proliferation of 3T3 cells. Proceedings of the National Academy of Sciences 72: 2635.
    CrossrefPubMedGoogle Scholar
  • 3 Antoniades H. N, Scher C. D. 1977; Radioimmunoassay of a human serum growth factor for Balb 1c-3T3 cells: Derivation from platelets. Proceedings of the National Academy of Sciences 74: 1973.
    CrossrefPubMedGoogle Scholar
  • 4 Baenziger N. L, Brodie G. N, Majerus P. W. 1971; A thrombin-sensitive protein of human platelet membranes. Proceedings of the National Academy of Sciences 68: 240.
    CrossrefPubMedGoogle Scholar
  • 5 Bagdasarian A, Colman R. W. 1975; Proteolytic inhibitors of human platelets. Federation Proceedings 34: 242.
    PubMedGoogle Scholar
  • 6 Bagdasarian A, Colman R. W. 1977 Subcellular localization and purification of platelet α1 antitrypsin. Blood. (in press).
    PubMedGoogle Scholar
  • 7 Balk S. 1971; Calcium as a regulator of the proliferation of normal, but not transformed chicken fibroblasts in a plasma containing medium. Proceedings of the National Academy of Sciences 68: 271.
    CrossrefPubMedGoogle Scholar
  • 8 Barber A. G, Käser-Glanzmann R, Jakabova M, Lüscher E. F. 1972; Characterization of chondroitin sulfate proteoglycan carrier for heparin neutralizing activity – (PF4) released from human blood platelets. Biochimica et biophysica acta 286: 312.
    CrossrefPubMedGoogle Scholar
  • 9 Bentfeld M. E, Bainton D. F. 1975; Cytochemical localization of lysosomal enzymes in rat megakaryocytes and platelets. Journal of Clinical Investigation 56: 1635.
    CrossrefPubMedGoogle Scholar
  • 10 Bolton A. E, Ludlam C. A, Pepper D. S, Moore S, Cash J. D. 1976; A radioimmunoassay for platelet factor 4. Thrombosis Research 8: 51.
    CrossrefPubMedGoogle Scholar
  • 11 Booyse F.M, Rafelson Jr. M. E. 1967; Stable messenger RNA in the synthesis of contractile protein in human platelets. Biochimica et biophysica acta 145: 188.
    CrossrefPubMedGoogle Scholar
  • 12 Boullin D. J, Votavova M, Green A. R. 1972; Protein synthesis by human blood platelets after accumulation of leucine and arginine. Thrombosis et Diathesis Haemorrhagica 28: 54.
    PubMedGoogle Scholar
  • 13 Broekman M. J, Westmoreland N. P, Cohen P. 1974; An improved method for isolating alpha granules and mitochondria from human platelets. Journal of Cell Biology 60: 507.
    CrossrefPubMedGoogle Scholar
  • 14 Broekman J. J, Handin R. I, Cohen P. 1975; Distribution of fibrinogen and platelet factors 4 and XIII in subcellular fractions of human platelets. British Journal of Haematology 31: 51.
    CrossrefPubMedGoogle Scholar
  • 15 Busch C, Wasteson Å, Westermark B. 1976; Release of a cell growth promoting factor from human platelets. Thrombosis Research 8: 493.
    CrossrefPubMedGoogle Scholar
  • 16 Castaldi P. A, Caen J. 1965 Platelet fibrinogen. 18. 579.
    PubMedGoogle Scholar
  • 17 Castor C. W, Ritchie J. C, Scott M. E, Whitney S. L. 1977; Connective tissue activation. XI. Stimulation of glycosaminoglycan and DNA formation by a platelet factor. Arthritis and Rheumatism 20: 859.
    CrossrefPubMedGoogle Scholar
  • 18 Chesney MC I, Harper E, Colman R. W. 1974; Human platelet collagenase. The Journal of Clinical Investigation 53: 1647.
    CrossrefPubMedGoogle Scholar
  • 19 Cooper I. A, Firkin B. G. 1970; Amino acid transport into human platelets and subsequent incorporation into protein. Thrombosis et Diathesis Haemorrhagica 23: 140.
    PubMedGoogle Scholar
  • 20 Cross M. J. 1964; Effect of fibrinogen on the aggregation of platelets by adenosine diphosphate. Thrombosis et Diathesis Haemorrhagica 72: 524.
    PubMedGoogle Scholar
  • 21 Da Prada M, Jakabova R, Lüscher E. F, Pletscher A, Richards J. G. 1976; Subcellular localization of the heparin neutralizing factor in blood platelets. Journal of Physiology 257: 495.
    CrossrefPubMedGoogle Scholar
  • 22 Davey M. G, Lüscher E. F. 1968; Release reactions of human platelets induced by thrombin and other agents. Biochimica et biophysica acta 165: 490.
    CrossrefPubMedGoogle Scholar
  • 23 Day H. J, Holmsen H, Hovig T. 1969 Subcellular particles of human platelets. A biochemical and electronmicroscopic study with particular reference to the influence of fractionation techniques. Scandinavian Journal of Haematology. Suppl. 7.
    PubMedGoogle Scholar
  • 24 Deuel T. F, Keim P. S, Farmer M, Heinrikson R. L. 1977; Platelet factor 4: complete amino acid sequence. Proceedings of the National Academy of Sciences 74: 2256.
    CrossrefPubMedGoogle Scholar
  • 25 Doolittle R. F, Takagi T, Cottrell B. A. 1974; Platelet and plasma fibrinogens are identical gene products. Science 185: 368.
    CrossrefPubMedGoogle Scholar
  • 26 Ehrlich H. P, Gordon J. L. 1976. Proteinases in platelets. In: Platelet Physiology. (ed.) Gordon J. L. Elsevier/North-Holland Biomedical Press; Amsterdan: 353.
    Google Scholar
  • 27 Ganguly P. 1969; Studies on platelet proteins. III. The identity of platelet and serum albumins. Biochimica et biophysica acta 188: 78.
    CrossrefPubMedGoogle Scholar
  • 28 Ganguly P. 1972; Isolation and some properties of fibrinogen from human blood platelets. Journal of Biological Chemistry 247: 1809.
    PubMedGoogle Scholar
  • 29 Gjesdal K. 1974; Platelet factor 4 (PF4): An electroimmunoassay for PF4in human plasma. Scandinavian Journal of Haematology 13: 232.
    PubMedGoogle Scholar
  • 30 Gjesdai K, Pepper D. S. 1977; Half-life of platelet factor 4 (PF4) in plasma and platelets from Macaca Mulatta. Thrombosis and Haemostasis 37: 73.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 31 Gocken M, Yunis E. 1963; Fibrinogen as a part of platelet structure. Nature 200: 590.
    PubMedGoogle Scholar
  • 32 Gospodarowicz D. 1975; Purification of a fibroblast growth factor from bovine pituitary. Journal of Biological Chemistry 250: 2515.
    PubMedGoogle Scholar
  • 33 Grette K. 1962; Studies on the mechanism of thrombin catalyzed hemostatic reactions in blood platelets. Acta Physiologica Scandinavica 56 Suppl. 195.
    PubMedGoogle Scholar
  • 34 Hagen I, Olsen T, Solum N. O. 1976; Studies on subcellular fractions of human platelets by the lactoperoxidase-iodination technique. Biochimica et biophysica acta 455: 214.
    CrossrefPubMedGoogle Scholar
  • 35 Handin R. I, Cohen H. J. 1976; Purification and binding properties of human platelet factor four. Journal of Biological Chemistry 251: 4273.
    PubMedGoogle Scholar
  • 36 Handin R. I. 1977. a Clinical application of radioimmunoassay for platelet factor 4. Platelet function testing. Proceedings from the Workshop on Platelets in Philadelphia, October 1976. (eds.) Day, Holmsen and Zucker. U. S. Government Press; 1977. (in press).
    Google Scholar
  • 37 Handin R. I, Mc Donough M. 1977; b Detection of two molecular forms of platelet factor 4 in human plasma. Clinical Research 25: 340 A (abstract).
    PubMedGoogle Scholar
  • 38 Harada K, Zucker M. B. 1971; Simultaneous development of platelet factor 4 activity and release of 14C-serotonin. Thrombosis et Diathesis Haemorrhagica 25: 41.
    PubMedGoogle Scholar
  • 39 Hawiger J, Collins R. D, Horn R. G. 1969; Precipitation of soluble fibrin monomer complexes by lysosomal fraction of polymorphonuclear leukocytes. Proceedings of the Society for Experimental Biology and Medicine 131: 349.
    PubMedGoogle Scholar
  • 40 Hawiger J, Niewiarowski S. 1975; Antiheparin factor of human platelets (platelet factor 4, PF4): Immunological detection in plasma, serum and during endotoxin induced release reaction in vitro. Blood 46: 1020 (abstract).
    PubMedGoogle Scholar
  • 41 Hennesy Jr. V. L, Hicks R. F, Niewiarowski S, Edmunds L. H, Colman R. W. 1977; Function of human platelets during extracorporeal circulation. American Journal of Physiology 232: 622-628.
    CrossrefPubMedGoogle Scholar
  • 42 Hermodson M, Schmer G, Kurachi K. 1977; Isolation, crystallization and primary aminoacid sequence of human platelet factor 4. Journal of Biological Chemistry 252: 6276.
    PubMedGoogle Scholar
  • 43 Hidaka H, Asano T. 1976; Platelet Cyclic 3’: 5’ – nucleotide phosphodiesterase released by thrombin and calcium ionophore. The Journal of Biological Chemistry 252: 7508.
    PubMedGoogle Scholar
  • 44 Hjort P, Rapaport S. I, Owren P. A. 1955; Evidence that platelet accelerator (platelet factor 1) is adsorbed plasma proaccelerism. Blood 10: 1139.
    PubMedGoogle Scholar
  • 45 Holmsen H, Day H. J. 1968; Thrombin-induced platelet release reaction and platelet lysosomes. Nature 219: 760.
    CrossrefPubMedGoogle Scholar
  • 46 Holmsen H, Day H. J. 1970; The selectivity of the thrombin-induced platelet release reaction: subcellular localization of released and retained constituents. Journal of Laboratory and Clinical Medicine 75: 849.
    PubMedGoogle Scholar
  • 47 Ihnatowycz I. O, Moore S, Mustard J. F. 1977; Platelet growth factor (PFG) stimulation of DNA synthesis in smooth muscle cells (SMC) in vitro. Federation Proceedings 36: 430 (abstract).
    PubMedGoogle Scholar
  • 48 James H. L, Bradford H. R, Ganguly P. 1975; Platelet fibrinogen. Identity and initial observations on the mode of its degradation by plasmin. Biochimica et biophysica acta 386: 209.
    CrossrefPubMedGoogle Scholar
  • 49 James H. L, Ganguly P, Jackson C. W. 1977 Characterization and origin of fibrinogen in blood platelets. A review. Thrombosis and Haemostasis. (in press).
    PubMedGoogle Scholar
  • 50 Joist J. H, Niewiarowski S. 1973; Retention of platelet fibrin stabilizing factor during the platelet release reaction and clot refraction. Thrombosis et Diathesis Haemorrhagica 29: 679.
    PubMedGoogle Scholar
  • 51 Joist J. H, Niewiarowski S, Nath N, Mustard J. F. 1976; Platelet antiplasmin: Its extrusion during the release reaction, subcellular localization, characterization and relationship to antiheparin in pig platelets. Journal of Laboratory and Clinical Medicine 87: 659.
    PubMedGoogle Scholar
  • 52 Kaplan K. L, Drillings M, Nossel H. L, Lesznik G. 1977. a Radioimmunoassay of β-thromboglobin (βTG) and platelet factor 4 (PF4). Platelet function tests. Proceedings from the Workshop on Platelets in Philadelphia, October 1976. (eds.) Day, Holmsen and Zucker. U. S. Government Press; 1977. (in press).
    Google Scholar
  • 53 Kaplan K. L, Nossel H. L. 1977; b Simultaneous measurement of platelet factor 4 (PF4) and β-thromboglobulin (βTG) release and fibrinopeptide A (FPA) cleavage. Clinical Researched 3 (abstract).
    PubMedGoogle Scholar
  • 54 Käser-Glanzmann R, Jakabova M, Lüscher E. F. 1972; Isolation and some properties of the heparin neutralizing factor (PF4) released from human blood platelets. Experientia 28: 1221.
    CrossrefPubMedGoogle Scholar
  • 55 Käser-Glanzmann R, Jakabova M, Lüscher E. F. 1972; 1973 Heparin-neutralizing factor (-platelet factor 4) from human blood platelets and its reactivity with fibrinogen and soluble fibrin monomer complexes. Hemostasis 1: 136.
    PubMedGoogle Scholar
  • 56 Keenan J. P. 1972; Platelet fibrinogen. I. Quantitation using fibrinogen sensitized tanned red cells. Medical Laboratory Technology 29: 71.
    PubMedGoogle Scholar
  • 57 Keenan J. P, Solum N. O. 1972; Quantitative studies on the release of platelet fibrinogen by thrombin. British Journal of Haematology 23: 461.
    CrossrefPubMedGoogle Scholar
  • 58 Kohler N, Lipton A. 1974; Platelets as a source of fibroblasts growth-promoting activity. Experimental Cell Research 87: 297.
    CrossrefPubMedGoogle Scholar
  • 59 Kopec M, Wegrzynowicz Z, Budzynski A. Z, Latallo Z. S, Lipinski B, Kowalski E. 1968; Interaction of fibrinogen degradation products with platelets. Experimental Biology and Medicine 3: 73.
    PubMedGoogle Scholar
  • 60 Kopec Wegrzynowicz Z, Latallo Z. S. 1970; Effects of some basic proteins and acid mucopolysaccharides on fibrin deposition. Thrombosis et Diathesis Haemorrhagica Suppl. 40: 253.
    PubMedGoogle Scholar
  • 61 Legrand Y, Caen J, Booyse F. M, Rafelson M. E, Robert B, Robert L. 1973; Studies on a human blood platelet protease with electrolytic activity. Biochimica et biophysica acta 309: 406.
    CrossrefPubMedGoogle Scholar
  • 62 Levine S. P, Wohl H. 1976; Human platelet factor 4 (PF4). Purification and characterization by affinity chromatography. Journal of Biological Chemistry 251: 324.
    PubMedGoogle Scholar
  • 63 Levine S. P, Krentz L. S. 1977 Development of a radioimmunoassay for human platelet factor 4. Thrombosis Research. (in press).
    PubMedGoogle Scholar
  • 64 Lopaciuk S, Lovette K. M, McDonagh J, Chuang H. Y. K, McDonagh R. P. 1976; Subcellular distribution of fibrinogen and Factor XIII in human blood platelets. Thrombosis Research 8: 453.
    CrossrefPubMedGoogle Scholar
  • 65 Ludlam C. A, Moore S, Bolton A. E, Pepper D. S, Cash J. D. 1975; The release of a human platelet specific protein measured by a radioimmunoassay. Thrombosis Research 6: 543.
    CrossrefPubMedGoogle Scholar
  • 66 Ludlam C. A, Cash J. D. 1976; Studies on the liberation of β-thromboglobulin from human platelets in vitro . British Journal of Haematology 33: 239.
    CrossrefPubMedGoogle Scholar
  • 67 Ludlam C. A, Anderton J. L. 1977. Platelet β-thromboglobulin. Platelet function tests. Proceedings from the Workshop on Platelets in Philadelphia, October 1976. (eds.) Day, Holmsen and Zucker. U.S. Government Press; (in press).
    Google Scholar
  • 68 Marcus A. J, Zucker-Franklin D, Safier L. B, Ullman H. L. 1966; Studies on human platelet granules and membranes. Journal of Clinical Investigation 45: 14.
    CrossrefPubMedGoogle Scholar
  • 69 Mills D. C. M, Robbs J. A, Roberts G. C. 1968; The release of nucleotides, 5-hydroxytryptamine and enzymes from human blood platelets during aggregation. Journal of Physiology 195: 715.
    CrossrefPubMedGoogle Scholar
  • 70 Moore S, Pepper D. S, Cash J. D. 1975; a The isolation and characterization of a platelet specific β-globulin (β-thromboglobulin) and the detection of anti-urokinase and anti-plasmin released from thrombin-aggregated washed human platelets. Biochimica et biophysica acta 379: 360.
    CrossrefPubMedGoogle Scholar
  • 71 Moore S, Pepper D. S. Cash 1975; b Platelet antiheparin activity: The isolation and characterization of platelet factor 4 released from thrombin-aggregated washed human platelets and its dissociation into subunits and the isolation of membrane-bound antiheparin activity. Biochimica et biophysica acta 379: 370.
    CrossrefPubMedGoogle Scholar
  • 72 Moore S, Pepper D. S. 1976. Identification of a platelet specific release product β-thromboglobulin. In: Platelet Physiology. (ed.) Gordon J. L. Elsevier/North Holland. Biomedical Press; Amsterdam: 293.
    Google Scholar
  • 73 Morgan F. J, Chesterman C. N, Mc Gready J. R, Begg G. S. 1977; a Studies on the chemistry of human platelet factor 4. Haemostasis 6: 53.
    PubMedGoogle Scholar
  • 74 Morgan F. J, Begg G. S, Chesterman C. N. 1977; b Primary structure of human platelet factor 4. Thrombosis and Haemostasis 38: 231 (abstract).
    PubMedGoogle Scholar
  • 75 Mui P. T. K, Kames H. L, Ganguly P. 1975; Isolation and properties of a low molecular weight antiplasmin of human blood platelets and serum. British Journal of Haematology 29: 627.
    CrossrefPubMedGoogle Scholar
  • 76 Murer E. H, Davenport K, Day H. J. 1976; a Metabolic aspects of the secretion of stored compounds from blood platelets. IV. Effects of ionophore X 537 A on washed platelets. Biochimica et biophysica acta 428: 369.
    CrossrefPubMedGoogle Scholar
  • 77 Mürer E. H, Davenport K, Rausch M. A, Day H. J. 1976; b Metabolic aspects of the secretion of stored compounds from blood platelets. V. Effect of ionophore A 23187 on washed platelets. Biochimica et biophysica acta 451: 1.
    CrossrefPubMedGoogle Scholar
  • 78 Murray J, Crawford G. P. M, Ogston D, Douglas A. S. 1974; Studies on an inhibitor of plasminogen activators in human platelets. British Journal of Haematology 26: 661.
    CrossrefPubMedGoogle Scholar
  • 79 Nachman R. L, Marcus A. J, Zucker-Franklin D. 1967; Immunological studies of protein associated with subcellular fractions of normal human platelets. Journal of Laboratory Clinical Medicine 69: 651.
    PubMedGoogle Scholar
  • 80 Nachman R. L, Ferris B. 1968; Studies of human platelet protease activity. Journal of Clinical Investigation 47: 2530.
    CrossrefPubMedGoogle Scholar
  • 81 Nachman R. L, Weksler B, Ferris B. 1970; Increased vascular permeability produced by human platelet granule cationic extract. Journal of Clinical Investigation 49: 274.
    CrossrefPubMedGoogle Scholar
  • 82 Nachman R. L, Webster B. 1972; The platelet as an inflammatory cell. Annals of the New York Academy of Sciences 201: 131.
    CrossrefPubMedGoogle Scholar
  • 83 Nachman R. L, Jaffe E. A. 1975; Subcellular platelet factor VIII antigen and von Willebrand factor. Journal of Experimental Medicine 141: 1101.
    CrossrefPubMedGoogle Scholar
  • 84 Nachman R. L, Harpel P. C. 1976; Platelet α2-macroglobulin and α1-antitrypsin. Journal of Biological Chemistry 251: 4514.
    PubMedGoogle Scholar
  • 85 Nath N, Niewiarowski S, Joist J. 1973; Platelet factor 4-antiheparin protein releasable from platelets, purification and properties. Journal of Laboratory and Clinical Medicine 82: 754.
    PubMedGoogle Scholar
  • 86 Nath N, Lowery C. T, Niewiarowski S. 1975; Antigenic and antiheparin properties of human platelet factor 4 (PF4). Blood 45: 537.
    PubMedGoogle Scholar
  • 87 Niewiarowski S, Poplawski A, Lipinski B, Farbiszewski R. 1968; The release of platelet clotting factors during aggregation and viscous metamorphosis. Experimental Biology and Medicine 3: 121.
    PubMedGoogle Scholar
  • 88 Niewiarowski S, Thomas D. P. 1969; Platelet factor 4 and adenosine diphosphate release during human platelet aggregation. Nature 222: 1269.
    CrossrefPubMedGoogle Scholar
  • 89 Niewiarowski S, Regoeczi E, Mustard J. F. 1972; Platelet interaction with fibrinogen and fibrin: Comparison of the interaction of platelets with that of fibroblasts, leukocytes and erythrocytes. Annals of the New York Academy of Science 201: 72.
    CrossrefPubMedGoogle Scholar
  • 90 Niewiarowski S, Senyi A. F, Gillies P. 1973; Plasmin-induced platelet aggregation and platelet release reaction. Journal of Clinical Investigation 52: 1647.
    CrossrefPubMedGoogle Scholar
  • 91 Niewiarowski S, Lowery C. T, Hawiger J, Millman M, Timmons S. 1976; Immunoassay of human platelet factor 4 (PF4, antiheparin factor) by radial immuno-diffusion. Journal of Laboratory and Clinical Medicine 87: 120.
    PubMedGoogle Scholar
  • 92 Niewiarowski S, Millman M. 1976; Potentiation of the thrombin-induced platelet release reaction by fibrin. Thrombosis Research 9: 181.
    CrossrefPubMedGoogle Scholar
  • 93 Niewiarowski S, Rucinski B, Millman M, Hawiger J. 1977. a Immunoassay of human platelet factor 4 (antiheparin factor) and its significance for evaluation of the platelet function. Platelet function tests. Proceedings from the Workshop on Platelets in Philadelphia, October 1976. (eds.) Day, Holmsen and Zucker. U. S. Government Press; 1977. (in press).
    Google Scholar
  • 94 Niewiarowski S, Kirby E, Stocker K. 1977; b Thrombocytin – A novel platelet activating enzyme from Bothrops atrox venom. Thrombosis Research 10: 863.
    CrossrefPubMedGoogle Scholar
  • 95 Østerud B, Rapaport S. I, Lavine K. K. 1977; Factor V activity of platelets: Evidence for an activated Factor V molecule and for a platelet activator. Blood 49: 819.
    PubMedGoogle Scholar
  • 96 Palade G. 1975; Intracellular aspects of the process of protein synthesis. Science 189: 311.
    PubMedGoogle Scholar
  • 97 Phillips D. R, Agin P. P. 1977; Platelet plasma membrane glycoprotein. Evidence for the presence of non equivalent disulfide bonds using non-reduced two dimensional gel electrophoresis. Journal of Biological Chemistry 252: 2121.
    PubMedGoogle Scholar
  • 98 Pifer D. D, Colman R. W, Mci. Chesney C. 1977; Subcellular localization and secretion of Factor V by human platelets. Thrombosis and Haemostasis 38: 126 (abstract).
    PubMedGoogle Scholar
  • 99 Robert B. Y, Legrand G, Pignand J, Caen J, Robert L. 1969; Acitivité élastinolytique associée aux plaquettes sanguines. Pathologie et Biologie 17: 615.
    PubMedGoogle Scholar
  • 100 Roberts R. R, Tew J. G, Donaldson D. M. 1977; Release of β-lysin from platelets caused by antigen-antibody complexes, purified enzymes and platelet-aggregating substances. Infection and Immunity 15: 485.
    PubMedGoogle Scholar
  • 101 Rosier O, Wegrzynowicz Z, Sawicki Z, Kopec M. 1970; Fibrinogen Synthesis in Blutplättchen. Folia Haematologica (Leipzig) 92: 552.
    PubMedGoogle Scholar
  • 102 Ross R, Glomset J, Kariya B, Harker L. 1974; A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proceedings of the National Academy of Sciences 71: 1207.
    CrossrefPubMedGoogle Scholar
  • 103 Ross R, Glomset J. A. 1976; The pathogenesis of atherosclerosis. New England Journal of Medicine 295: 369.
    CrossrefPubMedGoogle Scholar
  • 104 Rucinski B, Niewiarowski S, Budzynski A. Z. 1977; Separation of two antiheparin proteins secreted by human platelets. Federation Proceedings 36: 4278 (abstract).
    PubMedGoogle Scholar
  • 105 Rutherford R. B, Ross R. 1976; Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate. The Journal of Cell Biology 69: 196.
    CrossrefPubMedGoogle Scholar
  • 106 Schneider W, Doenecke C, Scheuerlen P. G. 1973. Synthesis of proteins and nucleic acids in human blood platelets. Erythrocytes, thrombocytes and leukocytes. Recent advances in membrane and metabolic research. (eds.) Gerlach E. et al. George Thieme Publishers; Stuttgart: 333.
    Google Scholar
  • 107 Schwartz M. L, Pizzo S. V, Hill R. L, McKee P. A. 1973; Human factor XIII from plasma and platelets. The Journal of Biological Chemistry 248: 1395.
    PubMedGoogle Scholar
  • 108 Siegel A, Lüscher E. F. 1967; Non-identity of the α-granules of human blood platelets with typical lysosomes. Nature 215: 745.
    CrossrefPubMedGoogle Scholar
  • 109 Solum N. O, Lopaciuk S. 1969; Bovine platelet proteins. III. Some properties of platelet fibrinogen. Thrombosis et Diathesis Haemorrhagica 21: 428.
    PubMedGoogle Scholar
  • 110 Steiner M, Baldini M. 1969; Protein synthesis in aging blood platelets. Blood 33: 628.
    PubMedGoogle Scholar
  • 111 Tangen O, Arfers K. E, Ceska M, McKenzie F. N. 1971; Presence of fibrinogen on the surface of platelets subjected to gel filtration. Federation Proceedings 30: 719 (abstract).
    PubMedGoogle Scholar
  • 112 Teien A. N, Lie M, Abildgaard U. 1976; Assay of heparin in plasma using a chromogenic substrate for activated factor X. Thrombosis Research 8: 413.
    CrossrefPubMedGoogle Scholar
  • 113 Tew J. G, Roberts R. R, Donaldson D. M. 1974; Release of β-lysin from platelets by thrombin and by a factor produced in heparinized blood. Infection and Immunity 9: 179.
    PubMedGoogle Scholar
  • 114 Tollefsen D. M, Majerus P. W. 1975; Inhibition of human platelet aggregation by monovalent antibody fragments. Journal of Clinical Investigation 55: 1259.
    CrossrefPubMedGoogle Scholar
  • 115 Walsh P. N. 1972; The effect of collagen and kaolin on the intrinsic coagulant activity of platelets. Evidence for an alternative pathway in intrinsic coagulation not requiring factor XII. British Journal of Haematology 22: 393.
    CrossrefPubMedGoogle Scholar
  • 116 Walsh P. N, Gagnatelli G. 1974; Platelet antiheparin activity: Storage site and release mechanism. Blood 44: 157.
    PubMedGoogle Scholar
  • 117 Walz D. A, Wu V. Y, de Lamo R, McCoy L. E. 1977 Primary structure of human platelet factor 4. Thrombosis Research. (in press).
    PubMedGoogle Scholar
  • 118 Warshaw A. L, Laster L, Shulman N. R. 1967; Protein synthesis by human platelets. Journal of Biological Chemistry 242: 2094.
    PubMedGoogle Scholar
  • 119 Wasteson A, Höök M, Westermark B. 1976; Demonstration of a platelet enzyme, degrading heparin sulphate. FEBS Letters 64: 218.
    CrossrefPubMedGoogle Scholar
  • 120 Wasteson A, Glimelius Busch C, Westermark B, Heldin H, Norling B. 1977 Effect of a platelet endoglycosidase on cell surface associated heparin sulphate of human cultured endothelial and glial cells. Thrombosis Research. (in press).
    PubMedGoogle Scholar
  • 121 Ward P. A, Hill J. H. 1970; C5 chemotactic fragments produced by an enzyme in lysosomal granules of neutrophils. Journal of Immunology 104: 535.
    PubMedGoogle Scholar
  • 122 Weksler B, Nachman R. L. 1971; Rabbit platelet bactericidal protein. Journal of Experimental Medicine 134: 1114.
    CrossrefPubMedGoogle Scholar
  • 123 Weksler B. B, Coupal C. E. 1973; Platelet-dependent generation of chemotactic activity in serum. The Journal of Experimental Medicine 137: 1419.
    CrossrefPubMedGoogle Scholar
  • 124 Westermark B, Wasteson A. 1976; A platelet factor stimulating human normal glial cells. Experimental Cell Research 98: 170.
    CrossrefPubMedGoogle Scholar
  • 125 Youssef A. H, Barkhan P. 1968; Release of platelet factor 4 by adenosine diphosphate and other platelet aggregating agents. British Medical Journal 1: 746.
    CrossrefPubMedGoogle Scholar
  • 126 Zucker M. B, Borrelli J. 1955; Relationship of some blood clotting factors to serotonin release from washed platelet. Journal of Physiology 7: 432.
    PubMedGoogle Scholar