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Thromb Haemost 1977; 38(04): 1002-1009
DOI: 10.1055/s-0038-1651918
Original Article
Schattauer GmbH

Malondialdehyde Production by Platelets during Secondary Aggregation

D. E Macfarlane
1   Specialized Center for Thrombosis Research, Temple University Hospital, 3401 North Broad Street, Philadelphia, Pennsylvania, 19140, U.S.A.
,
Sheila Gardner
1   Specialized Center for Thrombosis Research, Temple University Hospital, 3401 North Broad Street, Philadelphia, Pennsylvania, 19140, U.S.A.
,
Carol Lipson
1   Specialized Center for Thrombosis Research, Temple University Hospital, 3401 North Broad Street, Philadelphia, Pennsylvania, 19140, U.S.A.
,
D. C. B Mills
1   Specialized Center for Thrombosis Research, Temple University Hospital, 3401 North Broad Street, Philadelphia, Pennsylvania, 19140, U.S.A.
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Publikationsdatum:
04. Juli 2018 (online)

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Summary

A method is described for increasing the sensitivity of the thiobarbiturate assay for malondialdehyde by concentrating the coloured reaction product. The basal level of malondialdehyde-like material in plasma was found to be about 0.03 μM. Platelets synthesized malondialdehyde when stimulated by collagen or thrombin and also during the second phase of aggregation induced by ADP or adrenaline.

 

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