Prostaglandin Endoperoxide – Thromboxane Synthesis and Dense Granule Secretion as Positive Feedback Loops in the Propagation of Platelet Responses during “The Basic Platelet Reaction”

Holm Holmsen

doi:10.1055/s-0038-1651921

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1977; 38(04): 1030-1041
DOI: 10.1055/s-0038-1651921

Original Article

Schattauer GmbH

Prostaglandin Endoperoxide – Thromboxane Synthesis and Dense Granule Secretion as Positive Feedback Loops in the Propagation of Platelet Responses during “The Basic Platelet Reaction”

Authors

Holm Holmsen

¹Specialized Center for Thrombosis Research, Temple University Health Science Center, Philadelphia, Pa. 19140, U.S.A.

Abstract

Summary

Platelets respond to a great variety of stimuli by a sequential display of shape change, aggregation, prostaglandin/thromboxane synthesis – dense granule secretion and α-granule secretion. It is suggested that these responses are independent of each other, and caused by an increase in the concentration of a second messenger, liberated to the cytoplasm through the interaction between an extracellular agonist and the platelet membrane. The extent of the propagation of responses is determined by the strength of the stimulus. Stimuli can be subdivided into 1) original, applied stimuli and 2) platelet-produced stimuli (substances secreted from dense granules, prostaglandins and thromboxanes); these stimuli may act synergistically. In this way the platelet has two apparently independent means of potentiating their response to external stimuli which act as two separate positive feedback loops.

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References

References
1 Baumgartner H. R, Born G. V. R. 1968; Effects of 5-hydroxytryptamine on platelet aggregation. Nature 218: 137.
2 Bills T. K, Smith J. B, Silver M. J. 1976; Metabolism of [¹⁴C] arachidonic acid by human platelets. Biochimica et Biophysica Acta 424: 303.
3 Born G. V. R. 1970; Observations on the change in shape of blood platelets brought about by adenosine diphosphate. Journal of Physiology 209: 487.
4 Charo I. F, Feinman R. D, Detwiler T. C. 1976; Inhibition of platelet secretion by an antagonist of intracellular calcium. Biochemical and Biophysical Research Communications 72: 1462.
5 Charo I. F, Feinman D, Detwiler T. C, Smith J. B, Ingerman C. M, Silver M. J. 1977; Independent induction of platelet aggregation and secretion by prostaglandin endoperoxides and thromboxane A₂-like material. Nature 265: 66.
6 Derksen A, Cohen P. 1975; Patterns of fatty acid release from endogenous substrates by human platelet homogenates and membranes. Journal of Biological Chemistry 250: 9342.
7 Daniel J. L, Holmsen H, Adelstein R. S. 1977; Thrombin-stimulated myosin phosphorylation in intact platelets and its possible involvement in secretion. Thrombosis and Haemostasis 38: 984.
8 T. C. (1977): Personal Communication.
9 Feinman R. D, Detwiler T. C. 1974; Platelet secretion induced by divalent cation ionophores. Nature 249: 172.
10 Feinman R. D, Azbinski M. P, Lubowsky J. 1977. Simultaneous measurement of aggregation and secretion. In: Platelet Function Testing. (eds.) Day H. J, Holmsen H, Zucker M. B. US Government Printing Office; (DHEW-Pub-NIH-77-108), in press.
11 Feinstein M. B, Giekers K. J, Fraser F. B. 1975; An analysis of the mechanism of local anesthetic inhibition of platelet aggregation and secretion. Journal of Pharmacology and Experimental Therapeutics 197: 215.
12 Fukami M. H, Holmsen H, Bauer J. 1976; Thrombin-induced oxygen consumption, malondialdehyde formation and serotonin secretion in human platelets. Biochimica et Biophysica Acta 428: 253.
13 Fukami M. H, Salganicoff L. 1977; Human platelet storage organelles. Thrombosis and Haemostasis 38: 963.
14 Gerrard J. M, Peterson D, Townsend D, White J. G. 1976 Prostaglandins and platelet contraction. Circulation. 54. Abstract #767.
15 Hamberg M, Svensson J, Samuelsson B. 1975; Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proceedings of the National Academy of Sciences of the United States of America 72: 2994.
16 Haslam R. J, Lynham J. A. 1976; Increased phosphorylation of specific blood platelet proteins in association with the release reaction. Biochemical Society Transactions 4: 694.
17 Holme S, Holmsen H. 1975; ADP-induced refractory state of platelets in vitro. I. Methodological studies on aggregation in platelet-rich plasma. Scandinavian Journal of Haematology 15: 96.
18 Holme S, Sixma J. J, Wester J, Holmsen H. 1977; ADP-induced refreactory state of platelets in vitro II. Functional and ultra studies on gel filtered platelets. Scandinavian Journal of Haematology 18: 267.
19 Holmsen H. 1972; The platelet: its membrane, biochemistry and physiology. Clinics in Haematology 1: 235.
20 Holmsen H. 1974. Are platelet shape change, aggregation and release reaction tangible manifestations of one basic platelet function?. In: Baldini M. G, Ebbe S. (eds.) Platelets: Production Function Transfusion and Storage. Grune and Stratton; New York: 207.
21 Holmsen H, Setkowsky C. A, Day H. J. 1974; Effects of antimycin and 2-deoxyglucose on adenine nucleotides in human platelets. The role of metabolic ATP levels in primary aggregation, secondary aggregation and shape change of human platelets. Biochemical Journal 144: 385.
22 Holmsen H. 1975. Biochemistry of the platelet release reaction. In: Biochemistry and Pharmacology of Blood Platelets. CIBA Foundation Symposium, No. 35. Elsevier; Amsterdam: 175.
23 Holmsen H. 1976; Classification and possible mechanisms of action of some drugs that inhibit platelet aggregation. Series Haematologica 8: 50.
24 Holmsen H. 1977. Platelet energy metabolism in relation to function. In: Mills D. C B, Pareti F. I. (eds.) Platelets and Thrombosis. Acad. Press; New York: in press.
25 Holmsen H. and Dangelmaier C. A. (1977): Unpublished observations.
26 Holmsen H. and Robkin L. (1977): Unpublished observations.
27 Holmsen H, Setkowsky-Dangelmaier C. A. 1977; Adenine nucleotide metabolism of blood platelets. X. Formaldehyde stops centrifugation induced secretion after A 23187-stimulation and causes breakdown of metabolic ATP. Biochimica et Biophysica Acta 497: 46.
28 Kinlough-Rathbone R. L, Chahil A, Packham M. A, Reimers H.-J, Mustard J. F. 1975; Effect of ionophore A 23 187 on thrombin-degranulated washed rabbit platelets. Thrombosis Research 7: 435.
29 Kinlough-Rathbone R. L, Reimers H. J, Mustard J. F. 1976; Sodium arachidonate can induce platelet shape change and aggregation which are independent of the release reaction. Science 192: 1011.
30 Lages B. A, Weiss H. J. 1977; Platelet aggregation and secretion: Effects of anticoagulants and divalent cation chelators. (Abstract). Thrombosis and Haemostasis 38: 123.
31 Malmsten C, Hamberg M, Svensson J, Samuelsson B. 1975; Physiological role of an endoperoxide in human platelets: Hemostatic defect due to platelet cyclooxygenase deficiency. Proceedings of the National Academy of Sciences of the United States of America 72: 1446.
32 Mills D. C. B, Roberts G. C. K. 1967; Membrane active drugs and the aggregation of human blood platelets. Nature 213: 5071.
33 Mustard J. F, Perry D. W, Kinlough-Rathbone R. L, Packham M. A. 1975; Factors responsible of ADP-induced release reaction of human platelets. American Journal of Physiology 228: 1757.
34 Niewiarowski S, Thomas D. P. 1966; Platelet aggregation by ADP and thrombin. Nature 212: 1344.
35 O’Brien J. R. 1964; A comparison of platelet aggregation produced by seven compounds and a comparison of their inhibitors. Journal of Clinical Pathology 17: 275.
36 Packham M. A, Guccione M. A, Chang P. L, Mustard J. F. 1975; Platelet aggregation and release: effects of low concentration of thrombin or collagen. American Journal of Physiology 225: 38.
37 Ritchie J. M, Cohen P. J. 1975. Cocaine, procaine and other synthetic local anesthetics. In: Goodman L. S, Gilman A. (eds.) The pharmacological basis of therapeutics. Macmillan; New York: 379-386.
38 Rittenhouse-Simmons S, Russell F. A, Deykin D. 1976; Transfer of arachidonic add to human platelet plasmalogen in response to thrombin. Biochemical and Biophysical Research Communications 70: 295.
39 Ross R, Glomset J, Kariya B, Harker L. 1974; A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cell in vitro. Proceedings of the National Academy of Sciences of the United States of America 71: 1207.
40 Silver M. J, Smith J. B, Ingerman C, Kocsis J. J. 1973; Arachidonic acid-induced human platelet aggregation and prostaglandin formation. Prostaglandin 4: 863.
41 Smith J. B, Ingerman C, Kocsis J. J, Silver M. J. 1973; Formation of prostaglandins during the aggregation of human blood platelets. Journal of Clinical Investigation 52: 965.
42 Smith J. B, Ingerman C. M, Silver M. J. 1976; Malondialdehyde formation as an indicator of prostaglandin production by human platelets. Journal of Laboratory and Clinical Medicine 88: 167.
43 Smith J. B, Sedar A. W, Ingerman C. M, Silver M. J. 1977. Prostaglandin ednoperoxides: Platelet shape change, aggregation and the release reaction. In: Mills D. C. B. Pareti. (eds.) Platelets and Thrombosis. Acad. Press; New York: in press.
44 Taylor Jr F. B, Müller-Eberhard H. J. 1970; Qualitative description of factors involved in the retraction and lysis of dilute whole blood clots and in the aggregation and retraction of platelets. The Journal of Clinical Investigation 49: 2068.
45 Thomas D. P. 1968. The role of platelet catecholamines in the aggregation of platelets by collagen and thrombin. In: Hagen E, Wechsler W, Zillken F. (eds.) Experimental Biology and Medicine. S. Karger; New York: 129.
46 Walsh P. N, Mills D. C. B, White J. G. 1977; Metabolism and function of human platelets washed by albumin density gradient separation. British Journal of Haematology 36: 285.
47 Weiss H. J, Willis A. L, Kuhn D, Brand H. 1976; Prostaglandin E₂ potentiation of platelet aggregation induced by Lass endoperoxide: absent in storage pool disease, normal after aspirin ingestion. British Journal of Haematology 32: 257.
48 White J. G. 1969; The dense bodies of human platelets: Inherent electron opacity of the serotonin storage particles. Blood 33: 598.
49 White J. G. 1972; Interaction of membrane systems in blood platelets. American Journal of Pathology 66: 295.
50 White J. G. 1973; Shape Change. Thrombosis et Diathesis Haemorrhagica Suppl. 60: 159-171.
51 Zucker-Franklin D, Nachman R. L, Marcus A. J. 1967; Ultrastructure of thrombosthenin, the contractile protein of human blood platelets. Science 157: 945.