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Thromb Haemost 1981; 46(03): 621-622
DOI: 10.1055/s-0038-1653431
DOI: 10.1055/s-0038-1653431
Original Article
Subunit A of Factor XIII Regulates Subunit B Plasma Concentration
Further Information
Publication History
Received 13 January 1981
Accepted 28 July 1981
Publication Date:
05 July 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/198103/lookinside/thumbnails/10-1055-s-0038-1653431-1.jpg)
Summary
Subunit a of Factor XIII is found absent in homozygotes and reduced in heterozygotes. Since a concomitant reduction of subunit b occurs in these cases, an interaction between the loci controlling the synthesis of the two subunits was suggested. However in the present study we have shown that the administration of subunit a in two totally devoid homozygotes produced an increase of subunit b, reaching the maximum concentration five days after infusion. This strongly suggests that subunit b plasma level is regulated on the subunit a plasma amount.
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References
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