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Thromb Haemost 1981; 46(04): 710-713
DOI: 10.1055/s-0038-1653458
Original Article
Schattauer GmbH Stuttgart

Studies of a Fibrinolytic Enzyme from the Larvae of Lonomia achelous (Cramer) Using Chromogenic Peptide Substrates

C L Arocha-Piñango
*   The Instituto Venezolano de Investigaciones Científicas, Departamento de Medicina Experimental, Caracas, Venezuela
,
D S Pepper
**   The Scottish National Blood Transfusion Service, Headquarters Unit Laboratory, Edinburgh, Scotland
› Author Affiliations
Further Information

Publication History

Received 03 November 1980

Accepted 25 September 1981

Publication Date:
05 July 2018 (online)

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Summary

A fibrinolytic agent purified from the haemolymph, hair secretion and whole body extract of Lonomia achelous (Cramer)cleaves various chromogenic peptide substrates. The best substrate were found to be pyro-Glu-Gly-Arg-pNA (S-2444) followed by D-Pro-Phe-Arg-pNA (S-2302) and Bz-Ile-Glu-(or) Gly-Arg-pNA (S-2222) designed for urokinase, plasma kallikrein and factor Xa, respectively. Using substrate S-2251 we also found a plasminogen activator.

Keywords

Chromogenic substrates - Caterpillar extract - Fibrinolytic enzymes
 

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