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Thromb Haemost 1981; 46(04): 752-756
DOI: 10.1055/s-0038-1653469
Original Article
Schattauer GmbH Stuttgart

Comparison of Thrombelastography with Common Coagulation Tests

L Zuckerman
The Evanston Hospital, Department of Surgery and Medicine, Northwestern University, Vogelback Computing Center, Evanston, III., U.S.A
,
E Cohen
The Evanston Hospital, Department of Surgery and Medicine, Northwestern University, Vogelback Computing Center, Evanston, III., U.S.A
,
J P Vagher
The Evanston Hospital, Department of Surgery and Medicine, Northwestern University, Vogelback Computing Center, Evanston, III., U.S.A
,
E Woodward
The Evanston Hospital, Department of Surgery and Medicine, Northwestern University, Vogelback Computing Center, Evanston, III., U.S.A
,
J A Caprini
The Evanston Hospital, Department of Surgery and Medicine, Northwestern University, Vogelback Computing Center, Evanston, III., U.S.A
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Publikationsverlauf

Received 09. Oktober 1981

Accepted 30. Oktober 1981

Publikationsdatum:
05. Juli 2018 (online)

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Summary

Thrombelastography, although proven as a useful research tool has not been evaluated for its clinical utility against common coagulation laboratory tests. In this study we compare the thrombelastographic measurements with six common tests (the hematocrit, platelet count, fibrinogen, prothrombin time, activated thromboplastin time and fibrin split products). For such comparisons, two samples of subjects were selected, 141 normal volunteers and 121 patients with cancer. The data was subjected to various statistical techniques such as correlation, ANOVA, canonical and discriminant analysis to measure the extent of the correlations between the two sets of variables and their relative strength to detect blood clotting abnormalities. The results indicate that, although there is a strong relationship between the thrombelastographic variables and these common laboratory tests, the thrombelastographic variables contain additional information on the hemostatic process.

Keywords

Thrombelastography - Hematocrit - Platelets - Fibrinogen - Fibrin split products - P.T - A.P.T.T
 

  • References

  • 1 Howland WS, Castro EB, Fortner JB, Gould P. Hypercoagulability, thrombelastographic monitoring during extensive hepatic surgery. Arch Surg 1974; 108: 605-608
    CrossrefPubMedGoogle Scholar
  • 2 Raby C. Control of heparin therapy by thrombelastography. pp 211-218 In Kakkar VV, Thomas DP. ed Heparin: chemistry and clinical usage. Academic Press; London, England: 1976
    Google Scholar
  • 3 Raby C. Heparinotherapie controlee. Presse, Med 1976; 74: 1526
    PubMedGoogle Scholar
  • 4 Hume M. The relation of “hypercoagulability” to thrombosis. Surg Sri 1966; 2 (02) 133-158
    PubMedGoogle Scholar
  • 5 Collins GJ, Ahr DJ, Rich NM, Anderson CA. Detection and management of hypercoagulability. Am J Surg 1976; 132: 767-770
    CrossrefPubMedGoogle Scholar
  • 6 De Nicola P. Thrombelastography. Springfield, III, Charles C Thomas. 1957
    PubMedGoogle Scholar
  • 7 Merskey C. Pathogenesis and treatment of altered blood coagulability in patients with malignant tumors. Ann NY Acad Sri 1974; 230: 289-296
    PubMedGoogle Scholar
  • 8 Caprini JA, Zuckerman L, Cohen E, Vagher JP, Lipp V. The identification of accelerated coagulability. Thromb Res 1976; 9: 167-180
    CrossrefPubMedGoogle Scholar
  • 9 Cohen E, Caprini JA, Zuckerman L, Vagher P, Robinson B. Evaluation of three methods used to identify accelerated coagulability. Thromb Res 1977; 10: 587-604
    CrossrefPubMedGoogle Scholar
  • 10 Eliot RL, von Kaulla K, Blount SG. Thrombelastographic studies with a twenty-four hour schedule for subcutaneous heparin. Circulation 1961; 24: 1206-1214
    CrossrefPubMedGoogle Scholar
  • 11 Morrison FD. Multivariate statistical methods. McGraw Hill. 1976
    PubMedGoogle Scholar
  • 12 Dixon WG, Brown BM. Biomedical computer programs P-series. University of California Press; 1979
    Google Scholar
  • 13 von Kaulla KN. Continuous automatic recording of fibrin formation and fibrinolysis: A valuable tool for coagulation research. J Lab Clin Med 1957; 49: 304-312
    PubMedGoogle Scholar
  • 14 De Nicola P, Mazzetti GM. Evaluation of thrombelastography. Am J Clin Pathol 1955; 25: 447-452
    CrossrefPubMedGoogle Scholar
  • 15 Astrup T, Egablad K. Thrombelastographic patterns produced by fibrinolytic agents incorporated in fibrin. Am J Physiol 1965; 209: 84-94
    PubMedGoogle Scholar
  • 16 Ramstack JM, Zuckerman L, Mockros LF, Caprini JA, Vagher JP. Effect of platelet count and hematocrit on the coagulability of heparinized blood. Res Comm Chem Pathol Pharm 1978; 21: 327-342
    PubMedGoogle Scholar
  • 17 Gollub S, Schaefer C. Structural alteration in canine fibrin produced by celloid plasma expanders. Surg Gynecol Obstet 1968; 783-793
    PubMedGoogle Scholar
  • 18 Bick RL. Alterations of hemostasis associated with malignancy: Etiology, pathology, diagnosis and management. Thromb Haemostas 1978; 5: 1-26
    PubMedGoogle Scholar
  • 19 Stewart GJ. The role of hypercoagulability in thrombosis. Br J Haematol 1978; 40: 359-362
    CrossrefPubMedGoogle Scholar
  • 20 Hathaway WE, Hays T. Hypercoagulability in childhood cancer. J Pediatr Surg 1975; 10 (06) 893-899
    CrossrefPubMedGoogle Scholar
  • 21 Amundsen MA, Spittell JA, Thompson JH, Owen CA. Hypercoagulability associated with malignant disease and with the postoperative state. Ann Int Med 1963; 58 (04) 608-616
    CrossrefPubMedGoogle Scholar
  • 22 Nye SW, Graham JB, Brinkhouse KM. The partial thromboplastin time as screening test for detection of latent bleeders. Am J Med Sri 1962; 243: 279
    PubMedGoogle Scholar
  • 23 Quick AJ. The prothrombin time in hemophilia and in obstructive jaundice. J Biol Chem 1935; 109: 73
    PubMedGoogle Scholar
  • 24 Clauss A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogen. Acta Haematol 1957; 17: 237-246
    CrossrefPubMedGoogle Scholar
  • 25 Miale JB. Laboratory medicine. Haematology C V Mosley Co; St Louis, Mo: 1977
    Google Scholar
  • 26 Sigma Technical Bulletin No 850, Fibrinogen/fibrin degradation products in serum. 05/1977
    PubMed
  • 27 Hartert H. Klinische Blutgerinnungsstudien mit der Thrombelasto-graphie. Physiologische und methodische Grundlagen der Thrombela-stographie Dtsch Arch Klin Med 1952; 199: 234-292
    PubMedGoogle Scholar
  • 28 Hartert H. Thrombelastography. Thrombosis and bleeding disorders: Methods and theory. Bang, Beller, Deutsch, Mammen 70-76 Stuttgart, New York, London: 1970
    Google Scholar
  • 29 Zuckerman L, Ramstack JM, Vagher JP, Caprini JA, Mockros LF. Neutralization of heparin by cellular blood elements. Thromb Res 1975; 7: 149-159
    CrossrefPubMedGoogle Scholar
  • 30 Goodnight SH. Bleeding and intravascular clotting in malignancy: A review. Ann NY Acad Sri 1974; 230: 271-285
    PubMedGoogle Scholar