Production of the Generalized Shwartzman Reaction by Activated Hageman Factor and α-Adrenergic Stimulation

D.G McKay; J.-G Latour; Anatalia M. Lopez

doi:10.1055/s-0038-1653656

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1971; 26(01): 071-076
DOI: 10.1055/s-0038-1653656

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Production of the Generalized Shwartzman Reaction by Activated Hageman Factor and α-Adrenergic Stimulation

Authors

D.G McKay M. D

¹Department of Pathology University of California School of Medicine San Francisco General Hospital 1001 Potrero Avenue San Francisco, California 94110 U.S.A
J.-G Latour Ph. D

¹Department of Pathology University of California School of Medicine San Francisco General Hospital 1001 Potrero Avenue San Francisco, California 94110 U.S.A
Anatalia M. Lopez M. D

¹Department of Pathology University of California School of Medicine San Francisco General Hospital 1001 Potrero Avenue San Francisco, California 94110 U.S.A

Abstract

Summary

Infusion of activated purified Hageman factor and norepinephrine into pregnant rats produces renal glomerular capillary thrombosis identical to the generalized Shwartzman reaction. Activated Hageman factor alone, norepinephrine alone, and inosithin (a substitute for platelet phospholipid) alone, in addition to the combination of inosithin and norepinephrine were incapable of causing the reaction. These studies confirm the evidence that four basic components of the reaction are 1. activation of Hageman factor, 2. platelet phospholipid, 3. ‘‘fibrinolysin inhibition’’, and 4. stimulation of α-adrenergic receptor sites.

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References

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