Relationship between Plasma Fibrinolytic Activity and Serum Fibrinogen Degradation Products (FDP) Tested by Various Methods

B Lipiński; A Nowak; A Odrzywolska; J Dosiak

doi:10.1055/s-0038-1653658

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1971; 26(01): 083-087
DOI: 10.1055/s-0038-1653658

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Relationship between Plasma Fibrinolytic Activity and Serum Fibrinogen Degradation Products (FDP) Tested by Various Methods

B Lipiński

¹Department of Biochemistry, Postgraduate Medical School, Warszawa

²3rd Medical Department, Silesian School of Medicine, Katowice, Poland

,

A Nowak

¹Department of Biochemistry, Postgraduate Medical School, Warszawa

²3rd Medical Department, Silesian School of Medicine, Katowice, Poland

,

A Odrzywolska

¹Department of Biochemistry, Postgraduate Medical School, Warszawa

²3rd Medical Department, Silesian School of Medicine, Katowice, Poland

,

J Dosiak

¹Department of Biochemistry, Postgraduate Medical School, Warszawa

²3rd Medical Department, Silesian School of Medicine, Katowice, Poland

› Author Affiliations

Abstract

Summary

It was found in the present work that the level of serum fibrinogen degradation products (FDP) determined by the immunoassay method correlated well with the staphylococcal clumping titer in serum (correlation coefficient r = 0.68). The content of FDP in serum of 30 healthy subjects and patients with various diseases did not correlate, however, neither with blood fibrinolytic activity estimated by the euglobulin clot lysis time, nor with fibrinogen content and plasma anticlotting activity. It is concluded, that FDP appear in circulation as a result of local proteolytic degradation of intravascularly deposited fibrin without generalized activation of fibrinolysis.

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References

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