Download PDF
Thromb Haemost 1971; 26(02): 332-340
DOI: 10.1055/s-0038-1653681
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Disseminated Intravascular Coagulation and Acute Renal Failure

I Crîsnic
1   Medical Clinic I (Head: Prof. St. Hărăgus), Cluj, Romania
,
M Cucuianu
1   Medical Clinic I (Head: Prof. St. Hărăgus), Cluj, Romania
,
M Manasia
1   Medical Clinic I (Head: Prof. St. Hărăgus), Cluj, Romania
,
G Uza
1   Medical Clinic I (Head: Prof. St. Hărăgus), Cluj, Romania
› Author Affiliations
Further Information

Publication History

Publication Date:
28 June 2018 (online)

Also available at
    Permissions and Reprints

Summary

Starting from a hypothesis according to which disseminated intravascular coagulation might be an intermediary mechanism in the production of acute renal failure, investigations were made in 94 cases of anuria of different etiology, in order to detect signs of a consumption coagulopathy. After an average lapse of time of 48 h since the onset of anuria, the most frequently encountered hemostatic defect was a decreased platelet adhesiveness. In vitro experiments and clinical observations suggest that in the early stage of acute renal failure caused by a septic abortion, deficient platelet adhesiveness is due, mainly to platelet damage caused by intravascular coagulation or by bacterial toxins and not by the retention of metabolites. Euglobulin lysis time was prolonged, but a significant decrease of the plasminogen level indicates that an activation of fibrinolysis might have occured in the evolution of the process.

 

  • References

  • 1 Aljkjaersig N, Fletcher A. P, Sherry S. The mechanism of clot dissolution by plasmin. J. clin. Invest 38: 1086 1959;
    CrossrefPubMedSearch in Google Scholar
  • 2 Amerio A, De Benedictis G, Leondeff J, Mastrangelo F, Caratelli P. La nefrepatia da apiolo. Minerva nefrologica 15: 49 1968;
    PubMedSearch in Google Scholar
  • 3 Bluemle L. W, Webster B. D, Elkington J. R. Acute tubular necrosis. Analysis of 100 cases with respect to mortality complications and treatment with and without dialysis. Arch, intern. Med 104: 180 1959;
    PubMedSearch in Google Scholar
  • 4 Castaldi P. A, Rozemberg M. C, Stewart I. H. The bleeding disorder of uremia. A qualitative platelet defect. Lancet II: 66 1966;
    PubMedSearch in Google Scholar
  • 5 Cucucianu M. Betalipoproteins and euglobulin lysis time. Thrombos. Diathes. haemorrh. (Stuttg) 16: 687 1966;
    PubMedSearch in Google Scholar
  • 6 Cucuianu M, Papilian V. V, Bareliuc N, Crisnic I. Platelet adhesiveness and euglobulinlysis time in dogs given repeated infusion of sodium plamitate. Thrombos. Diathes. haemorrh. (Stuttg) 22: 164 1969;
    PubMedSearch in Google Scholar
  • 7 De la Huerga I, Yesinick G, Popper H. Colorimetric method for the determination of serum Cholinesterase. Amer. J. clin. Path 22: 1126 1952;
    PubMedSearch in Google Scholar
  • 8 Donner L, Neuwirtowa R. The hemostatic defect of acute and chronic uremia. Thrombos. Diathes. haemorrh. (Stuttg) 05: 319 1961;
    PubMedSearch in Google Scholar
  • 9 Hardaway R. M, MC Kay D. G, Williams J. H. Lower nephron nephrosis (Ischemuric nephrosis). Amer. J. Surg 87: 41 1954;
    CrossrefPubMedSearch in Google Scholar
  • 10 Hardaway R. M. Syndromes of disseminated intravascular coagulation. Ed. Thomas C. Springfield; Ill 1966.
  • 11 Hesse V. E, Mink I. B, Murphy G. P, Moore R. H, Ambrus I. L. Hemodialysis and hemostatic function. N.Y. St. J. Med 70: 1851 1970;
    PubMedSearch in Google Scholar
  • 12 Holdrinet A, Ewals M, Heanen C. A simple test for measuring platelet aggregation. Results in von Willebrand disease and uremia. Thrombos. Diathes. haemorrh. (Stuttg) 22: 174 1969;
    PubMedSearch in Google Scholar
  • 13 Horowitz H. I, Cohen B. D, Martinez P, Papayoanou M. F. Defective ADP induced platelet factor III activation in uraemia. Blood 30: 331 1967;
    PubMedSearch in Google Scholar
  • 14 Kendall A. G, Lowenstein L, Morgen R. O. The hemorrhagic diathesis in renal disease with special reference to acute uremia. Canad. med. Ass. J 85: 405 1961;
    PubMedSearch in Google Scholar
  • 15 Larrain C, Adelson E. The hemostatic defect of uremia. I. Clinical investigations of three patients with acute posttraumatic renal insufficiency. Blood 11: 1059 1956;
    PubMedSearch in Google Scholar
  • 16 Lasch H. G, Heene D. L. Diagnosis of intravascular coagulation and fibrinolysis. In: Platelets their role in hemostasis and thrombosis. 351 F.K. Schattauer; Stuttgart: 1967
    Search in Google Scholar
  • 17 Loewenstein L, Balew D. H. Fatal acute hemolytic anaemia, thrombocytopenic purpura, nephrosis and hepatitis resulting from ingestion of a compound containing apiol. Canad. M.A.J 78: 195 1958;
    PubMedSearch in Google Scholar
  • 18 Moriau M. Inhibiteurs naturels de la fibrinolyse et phénomènes thrombohémorrhagiques. Pathologia europaea 04 Suppl. 179 1969;
    PubMedSearch in Google Scholar
  • 19 Perlick E. Gerinnungslaboratorium in Klinik und Praxis. G. Thieme; Leipzig: 1960
    Search in Google Scholar
  • 20 Rath C. E, Maillard I. A, Schreiner G. E. Bleeding tendency in uremia. N. Engl. J. Med 257: 808 1957;
    CrossrefPubMedSearch in Google Scholar
  • 21 Ratnojf O. D, Menzie C. A new method for the determination of fibrinogen in small samples of plasma. J. Lab. clin. Med 37: 316 1951;
    PubMedSearch in Google Scholar
  • 22 Salzman E. W, Neri L. L. Adhesiveness of blood platelets in uraemia. Thrombos. Diathes. haemorrh. (Stuttg) 15: 84 1966;
    PubMedSearch in Google Scholar
  • 23 Sorrier J. B, Stewart J. H, Castaldi P. A. The Effect of urea on the aggregation of normal human platelets. Thrombos. Diathes. haemorrh. (Stuttg) 19: 64 1969;
    PubMedSearch in Google Scholar
  • 24 Spöttl F, Constantini R. Die Bedeutung des Proaktivators im fibrinolytischen Fermentsystem. Thrombos. Diathes. haemorrh. (Stuttg) 18: 416 1967;
    PubMedSearch in Google Scholar
  • 25 Steichele D. T, Herschlein H. J. Untersuchung über die Fibrinolyse bei Äquivalenten des Sanarelli-Schwartzman Phänomen in der Geburtshilfe. Immunochemischer Nachweis von Fibrin(ogen)derivaten. Thrombos. Diathes. haemorrh. (Stuttg) 18: 311 1967;
    PubMedSearch in Google Scholar
  • 26 De Vries S. I, ten Cate J. W, den Hartog M. E. Veerman Quelques remarques sur la throm- bocytopathie acquise des urémiques. Hématologia 02: 89 1968;
    PubMedSearch in Google Scholar
  • 27 Weber E, Malessa S, Lasch H. G. Veränderungen der freien Thrombocytennukleotide beim Sanarelli-Schwartzman Phänomen. Thrombos. Diathes. haemorrh. (Stuttg) 09: 304 1963;
    PubMedSearch in Google Scholar
  • 28 Wright H. P. Adhesiveness of blood platelet in normal subjects and with varying concentrations of anticoagulants. J. Path. Bact 53: 255 1941;
    CrossrefPubMedSearch in Google Scholar