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Thromb Haemost 1971; 26(03): 417-425
DOI: 10.1055/s-0038-1653694
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Disseminated Intravascular Coagulation in Experimental Heatstroke

T Rosenthal
1   Heller Institute of Medical Research and Haematological Department, Tel-Hashomer Hospital, Tel-Aviv University Medical School
,
Y Shapiro
1   Heller Institute of Medical Research and Haematological Department, Tel-Hashomer Hospital, Tel-Aviv University Medical School
,
U Seligsohn
1   Heller Institute of Medical Research and Haematological Department, Tel-Hashomer Hospital, Tel-Aviv University Medical School
,
B Ramot
1   Heller Institute of Medical Research and Haematological Department, Tel-Hashomer Hospital, Tel-Aviv University Medical School
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Publikationsdatum:
28. Juni 2018 (online)

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Summary

Heatstroke was induced experimentally in dogs, in order to clarify the mechanism of haemorrhage in that disorder.

Controls were provided both by dogs subjected to maximal effort at normal ambient temperatures and by dogs exposed to high enviromental temperature without exercise.

It was found that above a critical temperature (43.3° C), dogs show a typical clinical and laboratory picture of heatstroke, similar to that occurring in human beings.

Quick value and platelets dropped markedly, as did most of the clotting factors including factor V, II, VII and X.

Factor VIII was sometimes raised, but also fell terminally. Significant fibrinolysis and shortened half life of labelled fibrinogen were further strong indications of general defibrination.

The post-mortem presence of thrombi, provided confirmatory evidence of diffuse intravascular clotting (consumption coagulopathy).

 

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