Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1971; 26(03): 488-492DOI: 10.1055/s-0038-1653701 Originalarbeiten – Original Articles – Travaux Originaux Schattauer GmbH Effect of Congo Red on Blood Platelets and Leucocytes of Rabbits and Cats Authors Author Affiliations Th B. Tschopp 1 Department of Experimental Medicine, F. Hoffmann-La Roche & Co. Ltd, Basle, Switzerland H.-R Baumgartner 1 Department of Experimental Medicine, F. Hoffmann-La Roche & Co. Ltd, Basle, Switzerland A Studer 1 Department of Experimental Medicine, F. Hoffmann-La Roche & Co. Ltd, Basle, Switzerland Recommend Article Abstract Buy Article(opens in new window) Summary In rabbits and cats Congo red administered intravenously causes severe thrombocytopenia and ultrastructural alterations of platelets and leucocytes, similar to those produced by some fatty acids and endotoxin. Transient leucopenia is followed by leucocytosis. In contrast, incubation of Congo red in citrated blood or platelet rich plasma has no effect. Therefore, an indirect mechanism is postulated to explain the in vivo effect of Congo red. Full Text References References 1 Baumgartner H-JR. 5-Hydroxytryptamine, uptake and release in relation to aggregation of rabbit platelets. J. Physiol 201: 409-423 1969; 2 Baumgartner H-R, Born G. V. R. The relation between the 5-HT content and aggregation of rabbit platelets. J. Physiol 201: 397-408 1969; 3 Bennhold H, Ott H, Wiech M. Über den Bindungsunterschied lebergängiger und nierengängiger Substanzen an die Serumeiweißkörper. Dtsch. med. Wschr 75: 11-15 1950; 4 Berneis K, Studer A. Personal communication. 5 Brecher G. E. P, Gronkite M. Schneidermann The reproducibility and constancy of the platelet count. J. clin. Path 23: 15-26 1953; 6 Brunnhofer H, Steiger K. Beitrag zur Herstellung von Injektionslösungen mit Farbstoffen. Pharm. Actahelvet 34: 110-122 1959; 7 Gaynor E, Bouvier G. A, Ritschard J, Denizot M, Spaet T. H. Endothelial lesions induced by Endotoxin. XIII Internat. Congress of Hematology, Munich August 2-8 1970; 8 Harrison G. A. Congo red test for amyloid disease. In: Chemical methods in clinical medicine. 576-577 Ed. Churchill J. & A. Ltd; London: 1957 9 Hörstensmeyer O. Tödlicher Zwischenfall nach intravenöser Injektion von Kongorot. Dtsch. med. Wschr 89: 1845-1848 1964; 10 Horowitz H. I, Prez R. M, des Hoch E. W. Effects of bacterial endotoxin on rabbit platelets. J. exp. Med 116: 619-633 1962; 11 Lendrum A. G, Fraser D. S, Sliddersand W, Henderson R. Studies on the character and staining of fibrin. J. clin. Pathol 15: 401-413 1962; 12 Meester W. D, Sekhar G. hN. The effect of epinephrine induced elevation of plasma free fatty acids on platelet aggregation in man. Fourth Conf. on blood platelets. Oak Ridge; Tenn. USA: June 23-24 1969 13 Shore P. A, Alpers H. S. Platelet damage and release of amines by microgram quantities of certain fatty acids. Fed. Proc 22: 504 1963; 14 Skjorten F. Studies on the ultrastructure of pseudopod formation in human blood platelets. Scand. J. Haemat 05: 401-414 1968; 15 Spielvogel A. R. An ultrastructural study of the mechanism of platelet endotoxin interaction. J. exp. Med 126: 235-249 1968; 16 Stewart G. J. Effect of endotoxin on the ultrastructure of liver and blood cells of hamsters. Brit. J. exp. Path 51: 114-117 1970; 17 Suzuki T, Fukada C. h. The mechanism of the serotonin releasing action of Congo red and the role of serotonin in colloid shock. Jap. J. Pharmacol 14: 363-374 1964; 18 Tschopp BTh. Aggregation of cat platelets in vitro. Thrombos. Diathes. haemorrh. (Stuttg) 23: 601-620 1969; 19 Tschopp BTh, Studer A. Unpublished data. 20 White J. G. Fine structural alterations induced in platelets by adenosine diphosphate. Blood 31: 604-622 1968; 21 Zbinden G. Laurie acid-induced thrombocytopenia and thrombosis in rabbits. Thrombos. Diathes. haemorrh. (Stuttg) 18: 57-65 1968;
