Conjugated Estrogens Shorten Bleeding Time in Uraemia: a Possible Role of Serotonin?

Jacek S Malyszko; Jolanta Malyszko; Arsalan Azzadin; W Buczko; M Mysliwiec

doi:10.1055/s-0038-1653744

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1995; 73(01): 164-165
DOI: 10.1055/s-0038-1653744

Letter to the Editor

Schattauer GmbH Stuttgart

Conjugated Estrogens Shorten Bleeding Time in Uraemia: a Possible Role of Serotonin?

Jacek S Malyszko

Nephrology Department, Medical School, Bialystok, Poland

,

Jolanta Malyszko

Nephrology Department, Medical School, Bialystok, Poland

,

Arsalan Azzadin

^*Pharmacodynamics Department, Medical School, Bialystok, Poland

,

W Buczko

^*Pharmacodynamics Department, Medical School, Bialystok, Poland

,

M Mysliwiec

Nephrology Department, Medical School, Bialystok, Poland

› Author Affiliations

Abstract

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References

References
1 Liu JK, Kosfeld RE, Marcum SG. Treatment of uraemic patients with conjugated estrogens. Lancet 1984; 2: 887-890
2 Livio M, Manucci PM, Vigano G, Mingaroli G, Lombardi R, Mecca G, Remuzzi G. Conjugated estrogens for the management of bleeding associated with renal failure. N Eng J Med 1986; 315: 731-735
3 DeClerck F, van Nueten JM. Platelet-mediated vascular contractions; inhibition of the serotonergic component by ketanserin. Thromb Res 1982; 27: 713-727
4 Malyszko J, Malyszko JS, Pietraszek M, Azzadin A, Mysliwiec M, Buczko W. Possible involvement of serotonin in the haemostatic action of DDAVP in patients with uraemia. In: Desmopressin in Bleeding Disorders. Mariani G, Mannucci PM, Cattaneo M. eds. Plenum Publishing Corporation; New York: 1993. pp 35-42
5 Mielke CH, Kaneshiro MM, Maher JA, Wessler PM, Rapaport SI. The standardized normal Ivy bleeding time and its prolongation by aspirin. Blood 1969; 34: 204-215
6 Ashcroft G, Crawforyxd TB, Binns JK, MacDougall EJ. Estimation of 5 hydroxytryptamine in human blood. Clin Chim Acta 1964; 9: 364-369
7 Drummond A, Gordon J. Rapid sensitive microassay for platelet 5 HT. Thromb Diathes Haemorrh (Stuttgart) 1974; 31: 366-367
8 Heistinger M, Stockenhuber F, Schneider B, Pabinger I, Brenner B, Wagner B, Blacke P, Lechner K, Kysle PA. Effect of conjugated estrogens on platelet function and prostacyclin generation in chronic renal failure. Kidney Int 1990; 38: 1181-1186
9 Soslau G, Brodsky I, Putatunda B, Packer J, Schwartz AB. Selective reduction of serotonin storage and ATP release in chronic renal failure patients platelets. Am J Haematol 1990; 35: 171-178
10 Buczko W, Gambino MC, De Gaetano G. Prolongation of rat tail bleeding time by ketanserin: mechanism of action. Eur J Pharmacol 1984; 103: 261-268
11 Collins GG S, Pryse-Davies J, Sandler M, Southgate J. Effect of pretreatment with oestradiol and progesterone and dopa on monoamine oxidase activity in the rat. Nature 1970; 226: 642-643
12 Colburn P, Buonassisi V. Estrogen-binding sites in endothelial cell cultures. Science 1978; 201: 817-819