Raised Plasma Fibrinogen Concentrations in Subjects Attending a Metabolic Ward - Relation to Family History and Vascular Risk Factors

Maurizio Margaglione; Giovanni Di Minno; Elvira Grondone; Gennaro Vecchione; Egidio Celentano; Giuseppe Cappucci; Mauro Giordano; Massimo Grilli; Pasquale Simone; Saverio Fusilli; Salvatore Panico; Mario Mancini

doi:10.1055/s-0038-1653824

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1995; 73(04): 579-583
DOI: 10.1055/s-0038-1653824

Original Articles

Clinical Studies

Schattauer GmbH Stuttgart

Raised Plasma Fibrinogen Concentrations in Subjects Attending a Metabolic Ward - Relation to Family History and Vascular Risk Factors

Maurizio Margaglione

The Clinica Medica, Istituto di Medicina Interna e Malattie Dismetaboliche, Universita’ di Napoli, and Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S, “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

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Giovanni Di Minno

The Clinica Medica, Istituto di Medicina Interna e Malattie Dismetaboliche, Universita’ di Napoli, and Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S, “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

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Elvira Grondone

The Clinica Medica, Istituto di Medicina Interna e Malattie Dismetaboliche, Universita’ di Napoli, and Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S, “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

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Gennaro Vecchione

The Clinica Medica, Istituto di Medicina Interna e Malattie Dismetaboliche, Universita’ di Napoli, and Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S, “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

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Egidio Celentano

The Clinica Medica, Istituto di Medicina Interna e Malattie Dismetaboliche, Universita’ di Napoli, and Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S, “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

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Giuseppe Cappucci

The Clinica Medica, Istituto di Medicina Interna e Malattie Dismetaboliche, Universita’ di Napoli, and Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S, “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

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Mauro Giordano

The Clinica Medica, Istituto di Medicina Interna e Malattie Dismetaboliche, Universita’ di Napoli, and Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S, “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

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Massimo Grilli

The Clinica Medica, Istituto di Medicina Interna e Malattie Dismetaboliche, Universita’ di Napoli, and Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S, “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

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Pasquale Simone

The Clinica Medica, Istituto di Medicina Interna e Malattie Dismetaboliche, Universita’ di Napoli, and Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S, “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

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Saverio Fusilli

The Clinica Medica, Istituto di Medicina Interna e Malattie Dismetaboliche, Universita’ di Napoli, and Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S, “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

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Salvatore Panico

The Clinica Medica, Istituto di Medicina Interna e Malattie Dismetaboliche, Universita’ di Napoli, and Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S, “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

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Mario Mancini

The Clinica Medica, Istituto di Medicina Interna e Malattie Dismetaboliche, Universita’ di Napoli, and Unita’ di Trombosi e Aterosclerosi, I.R.C.C.S, “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Italy

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Abstract

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Summary

We have evaluated plasma fibrinogen levels in 171 subjects attending a metabolic ward. As in the general population, a significant difference in plasma fibrinogen concentrations (p <0.05) was found between subjects with diabetes mellitus or hypertension and those without. However, fibrinogen was also abnormally high (p <0.05) when evaluated according to the presence of a family history of ischemic complications of atherosclerosis (p <0.05). In this setting, fibrinogen correlated with diabetes mellitus or hypertension as well as with familial risk, and the latter interacted with hypertension (p <0.05) in accounting for plasma fibrinogen.

The relationships between certain fibrinogen genotypes and familial risk have then been evaluated. Analysis of a locus (1.3 kb, HAE III digestion) of the promoter region of the BB fibrinogen gene, identified a polymorphic cutting site. The allele with the alternative restriction site (HI) was associated with mean fibrinogen levels which were 0.1-0.3 g/1 lower than those associated with the other allele (H2). This difference was not statistically significant. No obvious association was found between the familial risk and the presence of the H2 allele. We conclude that in a group of subjects from a metabolic ward, a positive family history for ischemic complications of atherosclerosis is consistently associated with high plasma fibrinogen levels. Interaction with hypertension significantly strengthens the association.

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Referenzen

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