Apparent Heterozygous Type II Protein C Deficiency Caused by the Factor V 506 Arg to GIn Mutation

Thromb Haemost 1995; 73(04): 731-732
DOI: 10.1055/s-0038-1653854

Letters to the Editor

Schattauer GmbH Stuttgart

Helen Ireland

¹Charing Cross and Westminster Medical School, London UK

,

Trevor Bayston

¹Charing Cross and Westminster Medical School, London UK

,

Elizabeth Thompson

¹Charing Cross and Westminster Medical School, London UK

,

Antonella Adami

¹Charing Cross and Westminster Medical School, London UK

,

Cristina Gonçalves

¹Charing Cross and Westminster Medical School, London UK

,

David A Lane

¹Charing Cross and Westminster Medical School, London UK

,

Guido Finazzi

²Ospedali Riuntiti di Bergamo, Italy

,

Tiziano Barbui

²Ospedali Riuntiti di Bergamo, Italy

References
1 Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognised mechanism characterised by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad USA 1993; 90: 1004-1008
2 Bertina RM, Koeleman BP C, Koster T, Rosendaal FR, Dirven RJ, de RondeH, van deVeldon, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67
3 Faioni EM, Franchi F, Asti D, Sacchi E, Bemardi F, Mannucci PM. Resistance to activated protein C in nine thrombophilie families: interference in a protein S functional assay. Thromb Haemost 1993; 70: 1067-1071
4 Faioni EM, Boyer-Neumann C, Franchi F, Wolff M, Meyer D, Mannucci PM. Another Protein S functional assay is sensitive to resistance to activated Protein C. Thromb Haemost 1994; 72: 648