Sites of Tissue Factor Pathway Inhibitor (TFPI) and Tissue Factor Expression under Physiologic and Pathologic Conditions

Bjarne Østerud; Madhu S Bajaj; Paul S Bajaj

doi:10.1055/s-0038-1653884

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1995; 73(05): 873-875
DOI: 10.1055/s-0038-1653884

Scientific and Standardization Committee Communications

Schattauer GmbH Stuttgart

Sites of Tissue Factor Pathway Inhibitor (TFPI) and Tissue Factor Expression under Physiologic and Pathologic Conditions

On behalf of the Subcommittee on Tissue Factor Pathway Inhibitor (TFPI) of the Scientific and Standardization Committee of the ISTH

Bjarne Østerud

The Department of Biochemistry, Institute of Medical Biology, University of Tromsø, Tromsø, Norway and Departments of Medicine and Biochemistry, St. Louis University, School of Medicine, St. Louis, MO, USA

,

Madhu S Bajaj

The Department of Biochemistry, Institute of Medical Biology, University of Tromsø, Tromsø, Norway and Departments of Medicine and Biochemistry, St. Louis University, School of Medicine, St. Louis, MO, USA

,

Paul S Bajaj

The Department of Biochemistry, Institute of Medical Biology, University of Tromsø, Tromsø, Norway and Departments of Medicine and Biochemistry, St. Louis University, School of Medicine, St. Louis, MO, USA

› Author Affiliations

Abstract

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Summary

Under normal conditions, TFPI expression is restricted to megakaryocytes and the endothelium of the microvasculature. It is not synthesized by normal hepatocytes or by the endothelium of larger vessels. In contrast, endothelium and peripheral blood cells do not express tissue factor under normal conditions. Expression of tissue factor under normal physiologic conditions is widespread and is localized in areas which are physically separated from the circulating blood. During an inflammatory response, circulating monocytes have been shown to express tissue factor, whereas in general, expression of tissue factor has not been observed in the endothelium. Adherent monocytes/macrophages express both tissue factor and TFPI under pathologic conditions. Whether or not circulating peripheral blood monocytes under inflammatory conditions express TFPI is not known.

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References

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