Fibrinolytic System in Patients with Hypertensive Cardiovascular Disease

J Prokopowicz; K Worowski; A Popławski; A Gabryelewicz; S Niewiarowski

doi:10.1055/s-0038-1654078

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1967; 17(01/02): 001-007
DOI: 10.1055/s-0038-1654078

Originalarbeiten - Original Articles - Travaux Originaux

Schattauer GmbH

Fibrinolytic System in Patients with Hypertensive Cardiovascular Disease^[*]

J Prokopowicz

¹Department of Physiological Chemistry (Head: Doc. S. Niewiaroivski, M. D.) and Second Department of Medicine (Head: Prof. J. Ghlebowski, M. D.), Medical School, Bialystok, Poland

,

K Worowski

¹Department of Physiological Chemistry (Head: Doc. S. Niewiaroivski, M. D.) and Second Department of Medicine (Head: Prof. J. Ghlebowski, M. D.), Medical School, Bialystok, Poland

,

A Popławski

¹Department of Physiological Chemistry (Head: Doc. S. Niewiaroivski, M. D.) and Second Department of Medicine (Head: Prof. J. Ghlebowski, M. D.), Medical School, Bialystok, Poland

,

A Gabryelewicz

¹Department of Physiological Chemistry (Head: Doc. S. Niewiaroivski, M. D.) and Second Department of Medicine (Head: Prof. J. Ghlebowski, M. D.), Medical School, Bialystok, Poland

,

S Niewiarowski

¹Department of Physiological Chemistry (Head: Doc. S. Niewiaroivski, M. D.) and Second Department of Medicine (Head: Prof. J. Ghlebowski, M. D.), Medical School, Bialystok, Poland

› Institutsangaben

Abstract

Summary

The fibrinolytic system has been studied in 37 patients with essential hypertension, with arterial hypertension of various etiology (renal hypertension and hypertension with atherosclerosis). It has been found that in all these patients euglobulin fibrinolysis is inhibited and fibrinogen, factor VIII, plasminogen, plasminogen proactivator and antiplasmin increase considerably.

On the basis of the above findings and other literature data, the authors present a hypothesis that the fibrinolytic system is involved in the regulation of arterial blood pressure and that the impairment of plasminogen activator production in the renal tissue is one of the contributory factors in the development of arterial hypertension.

Volltext

Referenzen

References
1 Abe K, Yoshinaga K, Miwa I, Aida M, Maebashi M, Watanabe N. Excretion of urinary kinin in man. Tokohu J. exp. Med 82: 270 1964;
2 Astrup T, Sterndorff I. Fibrinolysokinase activity in animal and human tissue. Acta physiol. scand 104: 41 1956;
3 Bach N, Guth P. S, Munson A. E. On the relationship between plasmin and kinin. Ann. N. Y. Acad. Sci 104: 53 1963;
4 Barraclough M. A, Mills I. H. Effect of bradykinin on renal function. Clin. Sci 28: 69 1956;
5 Boomgard J. Urokinase. En Onderzoek Naar de Uitscheiding en Functie. Academisch Proef-schrift. Drukkerij “Aemstelstad”; Amsterdam: 1965
6 Brainerd H, Margen S, Chatton M. J. Current Diagnosis and Treatment. Lange Medical Publications; Los Altos, California: 1966
7 Buluk K, Furman M. On the controlling function of the kidneys in fibrinolysis. Experientia (Basel) 18: 146 1962;
8 Buluk K, Malofiejew M. Otrzymywanie aktywatora fibrynolizy w nerce poza ustrojum (aktywator fibrynolizy w izolowanej nerce). Acta physiol. pol 14: 371 1963;
9 Buluk K, Malofijew M. Urokinase induced activation of kallikreinogen and the release of plasma kinins in renal blood. Acta Med. pol 6: 405 1965;
10 Czarniecki W. Badania nad krzepnięciem krwi w przpadkach niewydolnosci nerek. Pol. Arch. Med. wewnet. (To be published.)
11 Edelman R, Hartroft P. M. Localization of renin in juxtaglomerular cells of rabbit and dog through the use of the fluorescent-antibody technique. Circ. Res 9: 1069 1961;
12 Egeberg O. Blood coagulation in renal failure. Scand. J. clin. lab. Invest 14: 163 1962;
13 Freman G, Hartley Jr. G. Hypertension in a patient with an solitary ischemic kidney. J. A. M. A III: 1159 1938;
14 Goldblatt H, Lynch J, Hanzal R. F, Summerville W. W. Studies in experimental hypertension; the production of persistent elevation of systolic blood pressure by means of renal ischemia. J. exp. Med 59: 347 1934;
15 Gross R, Nieth H, Mammen E. Blutungsbereitschaft und Gerinnungsstörung bei Urämie. Klin. Wschr 36: 107 1958;
16 Haas E. Pole of the renin system in experimental hypertension in: Angiotensin Systems and Experimental Renal Diseases. Edited by Metcoff J. Proc. 14th Ann. Conf. Kidney, sponsored by National Kidney Disease Foundation. 41 Little, Brown; Boston: 1963
17 Haas E, Goldblatt H. Renin content of kidney in experimental renal and human essential hypertension. Amer. J. Physiol 197: 1103 1959;
18 Kicköfen B, Struwe F. E, Bramesfeld B, Westphal O. Über einige Beobachtungen am Uro-pepsinogen und am Plasminogen-Aktivator des menschlichen Urins. Biochem. Z 330: 467 1958;
19 Kowalski E, Kopeć M, Niewiarowski S. An evaluation of the euglobulin method for the determination of fibrinolysis. J. clin. Path 12: 215 1959;
20 Leadbetter W. F, Burckland C. C. Hypertension in unilateral renal disease. J. Urol 39: 611 1938;
21 Lewis G. P, Work T. Formation of bradykinin or bradykinin-like substances by the action of plasmin on plasma proteins. J. Physiol. (Lond.) 135: 7P 1957;
22 Malanowicz W, Czarniecki W. Badania tromboelastograficzne w niewydolnosci nerek. Pol. Arch. Med. wewnęt 36: 635 1966;
23 Mielnikow A. Sostojanije fibrinoliticzeskoj aktiwnosti krowi pri hipertoniczeskoj bolezni. Klin. Mied 42: 105 1964;
24 Niewiarowska M, Węgrzynowicz Z. Influence of dicumarol derivatives on plasma fibrinolytic system. Thrombos. Diathes. haemorrh. (Stuttg.) 3: 279 1959;
25 Niewiarowski S. L’adsorbtion des facteurs du système fibrinolytique par la bentonite. Pathol. Biol 7: 2557 1959;
26 Niewiarowski S, Prokowicz J, Poplawski A, Worowski K. Inhibition of dog fibrinolytic system in experimental tubular necrosis of kidney. Experientia (Basel) 20: 101 1964;
27 Niewiarowski S, Wolosowicz N. The in vivo effect of E-amino-caproic acid (EACA) on human plasma fibrinolytic system. Thrombos. Diathes. haemorrh. (Stuttg.) 15: 491 1966;
28 Nowak A, Zahorska-Markiewicz B. Aktywnosc urokinazy i fibrynoliza w chorobach nerek. Pol. Arch. Med. wewnęt 35: 653 1965;
29 Page J. H. Discussion in Hypertension-Neural and renal mechanisms. Circ. Res 11: 217 1962;
30 Painter R. H, Charles A. F. Characterization of soluble plasminogen activator from kidney cell cultures. Amer. J. Physiol 202: 1125 1962;
31 Ploug J, Kjeldgaard N. O. Urokinase an activator of plasminogen from human urine. I. Isolation and properties. Biochim. bioprrys. Acta 24: 278 1957;
32 Prokopowicz J, Rejniak L, Niewiarowski S, Worowski K. Fibrinolytic activity of tissue sections of the dog kidney. Thrombos. Diathes. haemorrh. (Stuttg.) 12: 396 1964;
33 Prokopowicz J, Worowski K, Poplawski A, Mysliwiec M, Niewiarowski S. Fibrinolytic system in dog in experimental renal (Goldblatt) hypertension. Experientia (Basel). (In press.)
34 Quick A. J. The physiology and pathology of haemostasis. Kimpton; London: 1951
35 Salmon J, Lecomte J. Kininogènes plasmatiques et fibrinolyse thérapeutique. Rev. franç. Et. clin. biol 5: 473 1963;
36 Schultz F. H. Das Fibrinogen. VEB Georg Thieme; Leipzig: 1963
37 Skeggs L. T, Kahn J. R, Shuway N. P. The isolation and assay of hypertensin from blood. J. blood J. exp. Med 71: 857 1940;
38 Soulier J. P, Larrieu M. J. Nouvelle methode de diagnostic de l’hemophilie. Dosage des facteurs antihemophiliques A et B. Sang 24: 205 1953;
39 Taquini Jr. A.C, Taquini A. C. The renin-angiotensin system in hypertension. Amer. Heart J 62: 558 1961;
40 Vogt W. Kinin formation by plasmin mediated by activation of kallikrein. J. Physiol. (Lond.) 168: 44 P 1963;
41 Worowski K, Niewiarowski S, Prokopowicz J. Fibrinolysis and fibrinogen breakdown products (antithrombin VI) in renal venous blood (RVB) in dog. Thrombos. Diathes. haemorrh. (Stuttg.) 12: 87 1964;

Fibrinolytic System in Patients with Hypertensive Cardiovascular Disease[*]

Fibrinolytic System in Patients with Hypertensive Cardiovascular Disease^[*]