Fibrinogen Recovery in Fibrinolytic Dogs

Summary

Hypoprothrombinemic dogs with or without a superimposed hypofibrinogenemia were allowed to recover spontaneously or under the influence of vitamin K. The hypoprothrombinemic status was corrected more rapidly in K-treated animals irrespective of the fibrinogenemic status.

Hypofibrinogenemic dogs, irrespective of supplemental vitamin K, showed a biphasic rate of recovery. The initial phase was accelerated when vitamin K was administered, the second phase was not altered by vitamin therapy.

It is suggested that vitamin K influence fibrinogen recovery in a manner analogous to its influence on prothrombin recovery; namely, “finalization” of precursor protein and accelerated release of the protein into the circulating fluid compartments.

^* USPHS Medical Student Training Grant 9-143-46-260737-10. In partial fulfillment of M. A. degree requirements.

^** Funded, in part by USPHS Grants S-RO1-AM08449 and 1 SO1 FR 05427-07.

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