Protection by Catatoxic Steroids against Phenindione Overdosage*

Summary

In rats the severe and often fatal hemorrhagic diathesis induced by phenindione overdosage can be prevented by various catatoxic steroids such as ethylestrenol, SC-11927, spironolactone, norbolethone and oxandrolone. Conversely, steroids previously shown to possess no catatoxic potency in other test systems offer little or no protection against phenindione intoxication.

^* This work was supported by the Ministère de la Santé, Québec, and by the Medical Research Council of Canada (Block Term Grant MT-1829).

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