The Interaction of Platelets with Polymer Surfaces

D. J Lyman; K. G Klein; J. L Brash; B. K Fritzinger

doi:10.1055/s-0038-1654126

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1970; 23(01): 120-128
DOI: 10.1055/s-0038-1654126

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

The Interaction of Platelets with Polymer Surfaces

I. Uncharged Hydrophobic Polymer Surfaces^[*]

D. J Lyman^**

¹Polymer Chemistry Department, Stanford Research Institute, Menlo Park, California 94025

,

K. G Klein

¹Polymer Chemistry Department, Stanford Research Institute, Menlo Park, California 94025

,

J. L Brash

¹Polymer Chemistry Department, Stanford Research Institute, Menlo Park, California 94025

,

B. K Fritzinger

¹Polymer Chemistry Department, Stanford Research Institute, Menlo Park, California 94025

› Institutsangaben

Abstract

Summary

A direct relationship has been shown between platelet adhesion and critical surface tension of uncharged hydrophobic polymers when the air-blood interface is avoided. The similarity of this relationship to the previously observed relationship between critical surface tension and surface thrombogenicity suggests a possible major role for platelet activation as the initiating step in the surface-induced coagulation of blood on uncharged, hydrophobic polymers. The apparent damaging effects of a blood-air interface, as indicated by unusually heavy platelet adhesion suggests that such interfaces should be avoided in all blood/surface studies.

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Referenzen

References
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