Consumption of Hageman Factor Activity in the Generalized Shwartzman Reaction Induced by Liquoid

G Müller-Berghaus; H. G Lasch

doi:10.1055/s-0038-1654150

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1970; 23(02): 386-404
DOI: 10.1055/s-0038-1654150

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Consumption of Hageman Factor Activity in the Generalized Shwartzman Reaction Induced by Liquoid

Its Prevention by Inhibition of Hageman Factor Activation^[*]

G Müller-Berghaus

¹Department of Medicine, Justus-Liebig-Universität, Giessen, Germany

,

H. G Lasch

¹Department of Medicine, Justus-Liebig-Universität, Giessen, Germany

› Author Affiliations

Abstract

Summary

The role of Hageman factor in triggering intravascular coagulation has been studied in rabbits injected intravenously with Liquoid. Besides changes of coagulation parameters characteristic of consumption coagulopathy (e.g. decrease in platelet counts, fibrinogen levels, factor V activity), a pronounced drop in Hageman factor activity was observed after injection of Liquoid. Likewise, the partial thromboplastin time became prolonged.

The activation of Hageman factor in vivo could be prevented by intravenous infusion of lysozyme. Twenty min after starting the lysozyme infusion, the partial thromboplastin time became prolonged from a mean of 29 sec to 108 sec. Animals infused with lysozyme and injected with a lethal dose of Liquoid did not develop a consumption coagulopathy. In the same manner, none of 10 animals treated with lysozyme developed the generalized Shwartzman reaction, whereas in the control group 19 out of 20 animals showed fibrin thrombi in the glomerular capillaries.

From the present study it may be concluded that the intravascular coagulation process after intravenous injection of Liquoid is triggered by Hageman factor activation.

Full Text

References

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