Coagulation Findings in Rats with Experimental Hypersplenism and Their Changes after Splenectomy and after Administration of Adrenaline

P Pudlák; I Farská; V Brabec; V Pospíšilová

doi:10.1055/s-0038-1654190

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1970; 17(03): 593-600
DOI: 10.1055/s-0038-1654190

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Coagulation Findings in Rats with Experimental Hypersplenism and Their Changes after Splenectomy and after Administration of Adrenaline

P Pudlák

¹Institute of Hematology and Blood Transfusion (Director: Prof .Dr. Jaroslav Hořejši, Dr. Sc.), Prague

,

I Farská

¹Institute of Hematology and Blood Transfusion (Director: Prof .Dr. Jaroslav Hořejši, Dr. Sc.), Prague

,

V Brabec

¹Institute of Hematology and Blood Transfusion (Director: Prof .Dr. Jaroslav Hořejši, Dr. Sc.), Prague

,

V Pospíšilová

¹Institute of Hematology and Blood Transfusion (Director: Prof .Dr. Jaroslav Hořejši, Dr. Sc.), Prague

› Author Affiliations

Abstract

Summary

1. The following coagulation changes were found in rats with experimental hypersplenism: a mild prolongation of the recalcification time, shortened times in Quick’s test, a lowered activity in plasma thrombin time and shortened times in the partial thromboplastin test. Concentrations of factor II, V, VII (+X), VIII and X did not differ from those of normal control rats.

2. The administration of adrenaline to hypersplenic rats induced the correction of the partial thromboplastin test, Quick’s test and plasma thrombin time to normal values. Concentrations of coagulation factors were not significantly changed. An increase was found in factor V.

3. Splenectomy performed in hypersplenic rats was followed by a shortened recalcification time, a prolongation of the partial thromboplastin test and of the test with partial thromboplastin and kaolin. A prolongation was also observed in Quick’s test. Complete correction of plasma thrombin time was not observed. The concentration of factor VII increased.

4. The administration of adrenaline to splenectomized rats with experimental hypersplenism did not induce any significant changes with the exception of a corrected plasma thrombin time and a decreased concentration of factor VIII.

5. A different reaction of factor VIII to adrenaline in normal and hypersplenic rats is pointed out.

Full Text

References

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