Studies on the Participation of Hageman Factor in Fibrinolysis^[*]

Summary

The specific inhibition of the kaolin-mediated Hageman factor activation by the polycations : lysozyme, spermine tetrahydrochloride, and cytochrome c was confirmed. These polycations were without any antiplasmin or antiplasminogen-activator activity when tested in a one-stage lysis system. However, marked inhibition of plasminogen-activator generation in normal plasma by these polycations was noted in the activator-generation test. The proposed role of Hageman factor as that of a lysokinase or indirect activator of plasminogen is supported by these experiments.

^*) Supported by NIH Grant No HE 01510.

^**) Trainee, NIH Cardiovascular Training Grant, No. HE 05486, awarded to the Department of Medicine, U .N. C. School of Medicine.

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