Impaired Fibrinolysis in Sickle Cell Disease

D Green; H. C Kwaan; G Ruiz

doi:10.1055/s-0038-1654205

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1970; 24(01/02): 010-016
DOI: 10.1055/s-0038-1654205

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Impaired Fibrinolysis in Sickle Cell Disease

Relation to Crisis and Infectionwith the technical assistance of Nancy Malandruccolo

D Green M. D.

¹Northswestern Division of Medicine and the Hektoen Institute for Medical Research, Cook County Hospital, and the Veterans Administration Research Hospital, Chicago, Illinois 60611

,

H. C Kwaan M. D.

¹Northswestern Division of Medicine and the Hektoen Institute for Medical Research, Cook County Hospital, and the Veterans Administration Research Hospital, Chicago, Illinois 60611

,

G Ruiz M. D.

¹Northswestern Division of Medicine and the Hektoen Institute for Medical Research, Cook County Hospital, and the Veterans Administration Research Hospital, Chicago, Illinois 60611

› Author Affiliations

Abstract

Summary

Coagulation studies were performed in 52 patients with sickle cell disease during asymptomatic periods and during episodes of crisis and infection. Platelet counts averaged 473,000, 469,000, and 461,000 per mm³ in these 3 groups, and factor VIII concentrations were elevated in all. Fibrinogen was increased to the same extent in both sickle cell and non-sickle cell patients with infection. Fibrinolytic activity, as measured by euglobulin lysis times and zones of lysis on fibrin plates, was markedly reduced during periods of infection in sickle cell patients but not in non-sickle patients. Impairment of fibrinolysis in most patients was not on the basis of overutilization or consumption, since no decrease in the levels of clotting factors or plasminogen was observed. It was suggested that generalized intravascular sickling in these patients may have caused widespread endothelial damage, resulting in decreased production of plasminogen activator.

In addition, several sickle cell patients with infection were found to possess elevated levels of an inhibitor directed against urokinase.

Full Text

References

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