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Thromb Haemost 1970; 24(01/02): 214-223
DOI: 10.1055/s-0038-1654227
DOI: 10.1055/s-0038-1654227
Originalarbeiten – Original Articles – Travaux Originaux
The Adsorption of Coagulation Factors onto Phospholipids
Its Role in the Reaction Mechanism of Blood CoagulationFurther Information
Publication History
Publication Date:
28 June 2018 (online)
Summary
It is shown that factors VIII and IX react with phospholipid in a way fully analogous to the reaction of factors V and X. From this it is concluded that a complex of factors VIII and IX adsorbed onto a phospholipid micelle may be the entity that activates factor X in the intrinsic pathway. The implications of this finding for the concepts of the reaction mechanism of blood coagulation are discussed. It is shown that instead of the original 7-step cascade of Macfarlane, a 4-step cascade consisting partly of complex enzymes is more probable.
* Present address: Hôpital Universitaire St. Pierre, Service du Centre Albert Hustin, 322 Rue Haute, Bruxelles, Belgique.
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