The Adsorption of Coagulation Factors onto Phospholipids

H. C Hemker; M. J. P Kahn; P. P Devilee

doi:10.1055/s-0038-1654227

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1970; 24(01/02): 214-223
DOI: 10.1055/s-0038-1654227

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

The Adsorption of Coagulation Factors onto Phospholipids

Its Role in the Reaction Mechanism of Blood Coagulation

H. C Hemker

¹Laboratories of Coagulation Biochemistry and Cardiovascular Biochemical Research, Departments of Haematology and Cardiology, University Hospital, Leiden, The Netherlands

,

M. J. P Kahn^*

¹Laboratories of Coagulation Biochemistry and Cardiovascular Biochemical Research, Departments of Haematology and Cardiology, University Hospital, Leiden, The Netherlands

,

P. P Devilee

¹Laboratories of Coagulation Biochemistry and Cardiovascular Biochemical Research, Departments of Haematology and Cardiology, University Hospital, Leiden, The Netherlands

› Institutsangaben

Abstract

Summary

It is shown that factors VIII and IX react with phospholipid in a way fully analogous to the reaction of factors V and X. From this it is concluded that a complex of factors VIII and IX adsorbed onto a phospholipid micelle may be the entity that activates factor X in the intrinsic pathway. The implications of this finding for the concepts of the reaction mechanism of blood coagulation are discussed. It is shown that instead of the original 7-step cascade of Macfarlane, a 4-step cascade consisting partly of complex enzymes is more probable.

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Referenzen

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