Adhesive Platelet Count and Blood Coagulability in Myocardial Infarction and Cerebral Thrombosis

H Yamazaki; T Odakura; K Takeuchi; T Sano

doi:10.1055/s-0038-1654254

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1970; 24(03/04): 450-460
DOI: 10.1055/s-0038-1654254

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Adhesive Platelet Count and Blood Coagulability in Myocardial Infarction and Cerebral Thrombosis

H Yamazaki

¹Institute for Cardiovascular Diseases, Tokyo Medical and Dental University, School of Medicine, Yushima, Tokyo, Japan

,

T Odakura

¹Institute for Cardiovascular Diseases, Tokyo Medical and Dental University, School of Medicine, Yushima, Tokyo, Japan

,

K Takeuchi

¹Institute for Cardiovascular Diseases, Tokyo Medical and Dental University, School of Medicine, Yushima, Tokyo, Japan

,

T Sano

¹Institute for Cardiovascular Diseases, Tokyo Medical and Dental University, School of Medicine, Yushima, Tokyo, Japan

› Institutsangaben

Abstract

Summary

In 382 patients, aged 21 to 76 years, including 39 healthy volunteers, a platelet count by Olef’s method, an adhesive platelet count by Moolten-Vroman’s method, prothrombin activity due to one-stage prothrombin time and calcium clotting time were measured. In 39 cases of myocardial infarction and 40 cases of cerebral thrombosis, both in acute stage, a marked decrease in the adhesive platelet count and adhesive index and an increase of prothrombin activity were observed with statistical significance compared to the healthy group (P < 0.01). In the recovery stage of myocardial infarction, cerebral thrombosis and other diseases, except for malignant tumors, acute infectious diseases, diabetes mellitus and blood or liver diseases, the above observations were absent or reduced. In the case of thrombosis, a negative correlation was seen between the adhesive platelet count and prothrombin activity (r — —0.238, P < 0.01). There is no correlation between the changes in platelet adhesiveness or blood coagulability and total cholesterol level in serum.

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Referenzen

References
1 A classification and outline of cerebrovascular disease. A report by the Advisory Council for the National Institute of Neurological Diseases and Blindness. Public Health Service. Neurology 08: 395 1958;
2 Biggs R, Macfarlane R. G. Human blood coagulation and its disorders. 3rd Ed.. 384 Blackwell Scientific Publication; Oxford: 1957
3 Bobek K, CepalâJc V. Laboratory diagnosis of venous thrombosis. Acta med. scand 160: 121 1958;
4 Eisen M. E, Tyson M. G, Michael S, Bauman F. Adhesiveness of blood platelets in arteriosclerosis obliterans, thrombophlebitis, chronic venous insufficiency and arteriosclerotic heart disease. Circulation 03: 271 1951;
5 Feissly R. Physiopathologie des thromboses veineuses. In: Thrombose und Embolie. 1 Vol. 391 Schwabe & Co; Bale: 1954
6 Hartmann R. G. Platelet adhesiveness: The relation of platelets on glass surfaces. In: Platelets: Their Role in Hemostasis and Thrombosis. Ed. by Brinkhous K. M, Wright I. S, Soulier J. P, Roberts H. R, Hinnom S. 281 F.K. SchattauerVerlag; Stuttgart: 1967
7 Henly A. A. The determination of serum cholesterol. Analyst 82: 286 1957;
8 Horlick L. Platelet adhesiveness in normal persons and subjects with atherosclerosis. Amer. J. Cardiol 05: 459 1961;
9 McDonald L, Edgill M. Changes in coagulability of the blood during various phases of ischemic heart disease. Lancet I: 1115 1959;
10 Moolten S. E, Vroman L, Vroman G. MS. Adhesiveness of blood platelets in thromboembolism and hemorrhagic disorders. II. Diagnostic and prognostic significance of platelet adhesiveness. Amer. J. clin. Path 19: 814 1949;
11 Moolten S. E, Vroman L, Vroman G. MS, Goodman G. Role of blood platelets in thromboembolism. Arch, intern. Med 84: 667 1949;
12 Moolten S. E, Jennings P. B, Solden A. Dietary fat and platelet adhesiveness in arteriosclerosis and diabetes. Amer. J. Cardiol 11: 290 1963;
13 Murjphy E. A, Mustard J. F. Coagulation tests and platelet economy in atherosclerotic and control subjects. Circulation 25: 114 1962;
14 Olef I. The enumeration of blood platelets. J. Lab. clin. Med 20: 416 1935;
15 Owren P. A, Hellem A, Odegaard A. Lionleic acid and platelet adhesiveness. Lancet II: 849 1965;
16 Quick A. J. The prothrombin in hemophilia and in obstructive jaundice.J. biol. Chem 123: 109 1935;
17 Sano T. An immediate and transient thrombocytopenic reaction by adrenaline. Jap. J. int. Med 52: 1213 1964;
18 Shimamoto T. The relationship of edematous reaction in arteries to atherosclerosis and thrombosis. J. Atheroscler. Res 03: 87 1963;
19 Shimamoto T, Yamashita Y, Numano F, Sunaga T. The endothelial cell damage of preatheromatous and atheromatous lesions observed scanning electron microscope. Proc. Jap. Acad 45: 761 1969;
20 Weiner M, Zilmacker K, Reich G, Shapiro S. Platelet adhesiveness. Blood 03: 1275 1948;
21 Yamazaki H, Murase H, Shimamoto T, Shimamoto T. Appearance of platelet-clumping substance in plasma from humans with thrombosis, infection or tissue destruction. Proc. Jap. Acad 44: 1066 1968;
22 Yamazaki H, Sano T, Odakura T, Takeuchi K, Shimamoto T. Electrocardiographic and hematological changes by exercise test in coronary patients and pyridinolcarbamate pretreatment - a double blind crossover trial -. Amer. Heart J 79: 640 1970;
23 Zak B. Simple rapid microtechnic for serum total cholesterol. Amer. clin. Path 27: 583 1957;