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Thromb Haemost 1970; 24(03/04): 548-558
DOI: 10.1055/s-0038-1654265
Originalarbeiten – Original Articles – Travaux Originaux
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Contact and Plasmin Kinin-Forming Systems in the Blood[*]

K Buluk
1   Department of General and Experimental Pathology Medical School, Białystoic, Poland (Head: Prof. dr K. Buluk)
,
Maria Czokało
1   Department of General and Experimental Pathology Medical School, Białystoic, Poland (Head: Prof. dr K. Buluk)
,
M Małofiejew
1   Department of General and Experimental Pathology Medical School, Białystoic, Poland (Head: Prof. dr K. Buluk)
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Publication Date:
28 June 2018 (online)

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Summary

By means of preparations of two different kininogens, the existence of two kallikreins, postulated previously, that is one activated by the contact factor – contact kallikrein, and another by plasmin – plasmin kallikrein, has been confirmed.

Stasis plasma or plasma from blood taken without stasis incubated at 37 ° C can be a source of contact kallikrein.

It was found that modified plasma, that is plasma acidified to pH 2 and realkalized after 10 min, is suitable material for demonstrating that plasmin activates plasmin kallikrein. Plasmin kallikrein in the plasma has two substrates: kininogen – from which it releases kinins, and contact kallikrein which it inactivates. A diagram showing the activation of kinin-forming systems in the blood plasma is proposed.

* This investigation was supported partially by a grant from the Committee on Physiology, Section of Medical Sciences, Polish Academy of Sciences.


 

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