Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1970; 24(03/04): 572-576DOI: 10.1055/s-0038-1654268 Originalarbeiten – Original Articles – Travaux Originaux Schattauer GmbH Coagulant Activity Deposited on the Kiil Haemodialysis Membranes A Lurie * 1 Oxford Haemophilia Centre Research Laboratory, The Churchill Hospital, Headington, Oxford 0X3 7LJ, England , K. W. E Denson 1 Oxford Haemophilia Centre Research Laboratory, The Churchill Hospital, Headington, Oxford 0X3 7LJ, England › Author Affiliations Recommend Article Abstract Buy Article Summary A deposit present on the dialysing membranes of Kiil renal dialysis machines after extracorporeal haemodialysis has been found to have coagulant activity with features similar to phospholipid and to the thromboplastic activity of platelets. The deposition of the coagulant material occurred in spite of anti-coagulation with heparin. It is postulated that this coagulant material may render the extracorporeal blood hypercoagulable, and that this may be of significance in the pathogenesis of thrombosis in the shunt vasculature. Full Text References References 1 Bell W. N, Alton H. G. A brain extract as a substitute for platelet suspensions in the thromboplastin generation test. Nature (Lond.) 174: 880 1954; 2 Biggs R, Denson K. W. E, Riesenberg D, McIntyre C. The coagulant activity of platelets. Brit. J. Haemat 15: 283 1968; 3 Dale H. H, Laidlaw P. P. A simple coagulometer. J. Path. Bact 16: 351 1911; 4 Erickson R. V, Williman M, Pendras J. P. A true hypercoagulability state in patients on chronic haemodialysis. Trans. Amer. Soc. artif. intern. Org 12: 205 1966; 5 Gore I. In: Anderson W. A. D. (Editor), C.V. Mosby Co; St. Louis: Pathology. 5th. ed. 596 1966 6 Macfarlane R. G. An enzyme cascade in the blood clotting mechanism and its function as a biochemical amplifier. Nature (Lond.) 202: 498 1964; 7 Pendras J. P, Erickson R. V. Hemodialysis: A successful therapy for chronic uremia. Ann. intern. Med 64: 293 1966; 8 Schreiner G. E, Maher J. F, Freeman R. B, O’Connell J. M. B. Problems of haemodialysis. In: Proceedings of Third International Congress of Nephrology. 3: 316 Washington, D.C.: 1967 9 Schupak E, Merrill J. P. Experience with long-term intermittent hemodialysis. Ann. intern. Med 62: 509 1965; 10 Wing A. J, Curtis J. R, de Wardener H. E. Reduction of clotting in Scribner shunts by long-Term anticoagulation. Brit. med. J 03: 143 1967;
