Réactions Plaquettaires et Processus Immunitaires

Résumé

Nous avons étudié de quelle façon les substrats et inhiteurs de la chymotrypsine inhibent l’agrégation plaquettaire induite par le collagène. Nous avons trouvé que ces substances inhibent la libération d’ADP plaquettaire provoquée par le collagène.

Cette observation, ajoutée à plusieurs autres, indique que les processus plaquettaires et mastocytaires de libération de substances intracellulaires ont plusieurs caractéristiques biologiques communes.

Le rôle possible d’une estérase plaquettaire chymotrypsinoide dans les réactions de la thrombogénèse est discuté.

• Bibliographie

• 1 Jobin F, Tremblay F, Morissette M. Platelet reactions and immune processes. III. The inhibition of platelet aggregation by Chymotrypsin substrates and inhibitors. Thrombos. Diathes. haemorrh. (Stuttg.) 23: 110 1970;
• 2 Austen K. F, Brocklehurst W. E. Anaphylaxis in chopped guinea pig lung. I. Effect of peptidase substrates and inhibitors. J. exp. Med 113: 521 1961;
• 3 Keller R, Beeger I. Anaphylaxis in isolated rat mast cells. I. Effect of peptidase substrates and inhibitors. Int. Arch. Allergy 22: 31 1963;
• 4 Uvnas B. Metabolic and non-metabolic processes in the mechanism of histamine release from mast cells. In: Biochemistry of the acute allergy reactions. Ed. Austen K. F, Becker E. L. 131 Blackwell Scientific Publications; Oxford: 1968
• 5 Thon I. L, Uvnas B. Degranulation and histamine release, two consecutive steps in the response of rat mast cells to compound 48/80. Acta physiol, scand 71: 303 1967;
• 6 Packham M. A, Warrior E. S, Glynn M. F, Senyi A. S, Mustard J. F. Alteration of the response of platelets to surface stimuli by pyrazole compounds. J. exp. Med 126: 171 1967;
• 7 Markwardt F. Studies on the release of biogenic amines from blood platelets. In: Biochemistry of blood platelets. Ed. Kowalski E, Niewiarowski S. 105 Academic Press. London; 1967
• 8 Haslam R. J. Role of ADP in the aggregation of human blood platelets by thrombin and by fatty acids. Nature (Lond.) 202: 765 1964;
• 9 Jobin F, Tremblay F. Platelet reactions and immune processes. II. The inhibition of platelet aggregation by complement inhibitors. Thrombos. Diathes. haemorrh. (Stuttg.) 22: 466 1969;
• 10 Aster R. H, Jandl J. H. Platelet sequestration in man. I. Methods. J. clin. Invest 43: 843 1964;
• 11 Adam H. Adenosine 5’-diphosphate and adenosine -5’ - monophosphate. Dans “Methods of Enzymatic Analysis”, édité par H.-U. Bergmeyer. 573 Academic Press; New York et London: 1965.
• 12 Becker E. L, Austen K. F. A comparison of the specificity of inhibition by phosphonate esters of the first component of complement and the antigen-induced release of histamine from guinea pig lung. J. exp. Med 120: 491 1964;
• 13 Becker E. L, Austen K. F. Mechanisms of immunologic injury of rat peritoneal mast cells. I. The effect of phosphonate inhibitors on the homocytotropic antibody-mediated histamine release and the first component of rat complement. J. exp. Med 124: 379 1966;