Effect of Adrenaline on Thrombosthenin

S Levy-Toledano; J Caen; with the technical assistance of Eva Bodevin

doi:10.1055/s-0038-1654296

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1971; 25(02): 214-222
DOI: 10.1055/s-0038-1654296

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Effect of Adrenaline on Thrombosthenin

Implications for the Role of Thrombosthenin on Clot Retraction and Platelet Aggregation^[*]

S Levy-Toledano

,

J Caen^**

,

with the technical assistance of Eva Bodevin

Abstract

Summary

It has been found that adrenaline protects the two activities of thrombosthenin from inhibition by NEM if added before or with NEM but not if added after.

The α-blockers of epinephrine, phentolamine, abolishes the protective effect of adrenaline when it is added before adrenaline. We find the same results with noradrenaline but not with 5-hydroxytryptamine.

A parallemism exists between the effect of adrenaline on thrombosthenin and clot retraction, but not on platelet aggregation. This shows possibly that the activities of thrombosthenin are directly linked to clot retraction, but in platelet aggregation it seems that thrombosthenin is necessary but not sufficient.

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References

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