Thromb Haemost 1961; 6(01): 160-171
DOI: 10.1055/s-0038-1654549
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Bridge Anticoagulant, a New Entity?

E Mulder M.D.
1   Paediatric Clinic of the University of Amsterdam (Head: Prof. Dr. S. van Creveld)
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
12. Juli 2018 (online)

Summary

After a critical analysis of the work of Nour Eldin and Wilkinson on the so-called Bridge anticoagulant, the author presents his own experimental work on this subject. It is concluded that one part of the evidence for a new inhibitor is not reproduceable, and that the other part depends on the presence of an inhibitor, anticephalin. This inhibitor has been known to exist for many years.

 
  • References

  • (1) Nour Eldin F, Wilkinson J. F. Bridge anticoagulant: a hitherto unrecognized blood clotting inhibitor in hemophilic- and Christmas-disease plasma. A simple method for its demonstration. Brit. J. haemat. 4: 38 1958;
  • (2) Graham J. B, Barrow E. M. The pathogenesis of hemophilia. An experimental analysis of the hypothesis of anticephalin excess in hemophilic dogs. J. exp. Med. 106: 273 1957;
  • (3) Biggs R. M. The inhibitory effect of hemophilic plasma. Brit. J. haemat. 4: 192 1958;
  • (4) Hougie C. Pathogenesis of hemophilia. A critical analysis of the evidence for the Bridge anticoagulant. Brit. J. haemat. 5: 172 1959;
  • (5) Mulder E. Experimenteel-kritisch onderzoek over zogenaamde stollingsremmende fenomenen bij haemophilie A. Thesis Amsterdam: 1960
  • (6) Egli A, Klesper R. Untersuchungen über die Thrombokinasebildungsteste. Thromb. Diath. haem. 2: 39 1958;
  • (7) Bell N. N, Alton H. G. A brain extract as a substitute for the platelet suspension in the thromboplastin generation test. Nature (Lond.) 174: 880 1954;
  • (8) Ingram G. I. C, Tanner E. I, Matchett M. O. Experiments on the “Bridge effect”. Brit. J. haemat. 5: 307 1959;
  • (9) Bounameaux Y. Recherches sur le mechanisme de la formation de la thromboplastine sanguine. Acta haemat. (Basel) 17: 65 1957;
  • (10) Klein E, Florentino R. Effects of varying concentrations of platelets and their lyophilized derivatives on the generation of thromboplastin. Proc. Soc. exp. Biol. (N. Y.) 94: 357 1957;
  • (11) Miale J. B, Garrett V. R. Studies on the TGT. III. Effects of dilution, storage and concentration of platelets. Amer. J. clin. Path. 27: 701 1957;
  • (12) Spaet T. H. Anticoagulant effect of excess platelets in the TGT. J. clin. Invest. 35: 736 1956;
  • (13) Tocantins L. M. Demonstration of antithromboplastic activity in normal and hemophilic plasma. Amer. J. Physiol. 137: 265 1943;
  • (14) Tocantins L. M. Cephalin, protamin and the antithromboplastic activity of normal and hemophilic plasma. Proc. Soc. exp. Biol. (N. Y.) 54: 94 1943;
  • (15) Tocantins L. M. Separation and assay of a lipid antithromboplastin from human brain, plasma and plasma fractions. Tr. 2nd Josiah Macy Jr. Foundation Blood clotting section 2: 11.
  • (16) Creveld S. van, Veder H. A, Pascha C. N, Kroeze W. N. The separation of AHF from Fibrinogen. Thromb. Diath. haem. 3: 572 1959;