Les inhibiteurs de la fibrinolyse et le dosage de l’activité antiplasminique physiologique et pathologique

M Moriau; S. I de Vries; H. J Dik

doi:10.1055/s-0038-1654790

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1963; 10(02): 355-378
DOI: 10.1055/s-0038-1654790

Originalarbeiten — Original Article — Travaux Originaux

Schattauer GmbH

Les inhibiteurs de la fibrinolyse et le dosage de l’activité antiplasminique physiologique et pathologique

M Moriau

¹Laboratoire de la Transfusion Sanguine et d^}Hématologie du Wilhelmina Gasthuis, Amsterdam (Directeur: Dr. S. 1. de Vries)

,

S. I de Vries

¹Laboratoire de la Transfusion Sanguine et d^}Hématologie du Wilhelmina Gasthuis, Amsterdam (Directeur: Dr. S. 1. de Vries)

,

H. J Dik

¹Laboratoire de la Transfusion Sanguine et d^}Hématologie du Wilhelmina Gasthuis, Amsterdam (Directeur: Dr. S. 1. de Vries)

› Author Affiliations

Abstract

Résumé

Dans cet exposé une technique de dosage quantitatif de l’activité antiplas-minique sérique a été décrite. Ses variations sur 100 sujets normaux et dans certaines affections on été envisagées. Un dosage de l’activité antiplasminique pla-quettaire a été réalisé chez un certain nombre de patients présentant une thrombopathie liée à une myélofibrose ou polycythémie. Le fractionnement électro-phorétique ou au Rivanol des protéines du sérum ou d’un extrait plaquettaire normal a permis de localiser l’activité antiplasminique au sein des fractions alpha₁-, alpha₂-et gammaglobulines, et l’activité antitrypsique au sein de la fraction alpha₁-globuline. Diverses propriétés de certaines antiplasmines non sanguines ont également été mentionnées.

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References

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