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Thromb Haemost 1963; 10(02): 400-405
DOI: 10.1055/s-0038-1654793
Originalarbeiten — Original Article — Travaux Originaux
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Observations on a Relationship between Steroid Metabolism and the Concentration of Plasma Fibrinogen[*]

B. A Amundson
1   Arteriosclerosis Research Laboratory, St. Barnabas Hospital Research Foundation, and thi Department of Physiology, University of Minnesota School of Medicine, Minneapolis, Minnesota
,
L. O Pilgeram
1   Arteriosclerosis Research Laboratory, St. Barnabas Hospital Research Foundation, and thi Department of Physiology, University of Minnesota School of Medicine, Minneapolis, Minnesota
› Author Affiliations
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Publication History

Publication Date:
22 June 2018 (online)

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Summary

Enovid (5 mg norethynodrel and 0.075 mg ethynylestradiol-3-methyl ether) therapy in young normal human subjects causes an increase in plasma fibrinogen of 32.4% (P >C 0.001). Consideration of this effect together with other effects of Enovid on the activity of specific blood coagulatory factors suggests that the steroids are exerting their effect at a specific site of the blood coagulation and/or fibrinolytic system. The broad spectrum of changes which are induced by the steroids may be attributed to a combination of a chain reaction and feed-back control.

* This study has been supported in part by a research grant from G. D. Searle and Co., Chicago, Illinois; the U.S. Public Health Service Grant No. H-3697, American, Iowa and Minnesota Heart Associations; the Life Insurance Medical Research Fund, and the University of Minnesota Graduate School.


 

  • References

  • 1 Challerjea J. B, Solomon L. Antagonistic Effect of ACTH and Cortisone on the Anticoagulant Activity of Ethyl Biscoumacetate. Brit. med. J. II: 790 1954;
    PubMedSearch in Google Scholar
  • 2 Fazlullah S. Thromboembolic Complications During and After Cortisone and ACTH Therapy. Postgrad. med. J. 32: 444 1956;
    CrossrefPubMedSearch in Google Scholar
  • 3 De Nicola P. Bemerkungen über die Indikationen und Kontraindikationen der Antikoagulantientherapie auf Grund der gerinnungsphysiologischen Ergebnisse. Schweiz, med. Wschr. 84: 835 1954;
    PubMedSearch in Google Scholar
  • 4 Heftmann E, Mosettig E. Biochemistry of Steroids. New York: Reinhold Publishing Corp; 163 1960
    Search in Google Scholar
  • 5 Egeberg O, Owren P. A. Oral Contraception and Blood Coagulability. Brit. med. J. I: 220 1963;
    PubMedSearch in Google Scholar
  • 6 Morrison P. R. Preparation and Properties of Serum and Plasma Proteins. XV. Some Factors Influencing the Quantitative Determination of Fibrinogen. J. Amer. chem. Soc. 69: 2723 1947;
    CrossrefPubMedSearch in Google Scholar
  • 7 SzecsenyiNagy L. V. Gravimetrische Fibrinogenbestimmung im Blute. Biochem. 2. 317: 185 1944;
    PubMedSearch in Google Scholar
  • 8 Esser H, Heinzler F. Eine kolorimetrische Fibrinogenbestimmung mit der Biuret-Reaktion. Klin. Wschr. 30: 991 1952;
    CrossrefPubMedSearch in Google Scholar
  • 9 Saifer A, Newhouse A. Photometric Microdetermination of Plasma Fibrinogen with a Thrombin Ninhydrin Procedure. J. biol. Chem. 208: 159 1954;
    PubMedSearch in Google Scholar
  • 10 Pilgeram L. O, Amundson B. A, Commers L. R, Loegering D. A, Lofgren P. E. Effects of Steroid Therapy on Blood Coagulation. To be published.
    PubMed
  • 11 Pilgeram L. O, Schram A. C, Loegering D. A. Elevation of Plasma Antithrombin in the Aging Arteriosclerotic Subject. J. appl. Physiol. 18: 329 1963;
    CrossrefPubMedSearch in Google Scholar
  • 12 Cosgriff S. W, Diefenbach A. F, Vogt W. Hypercoagulability of the Blood Associated with ACTH and Cortisone Therapy. Amer. J. Med. 09: 752 1950;
    CrossrefPubMedSearch in Google Scholar
  • 13 Eisenmenger W. T, Slater R. J, Bongiovanni A. M. Hypercoagulability of the Blood of Patients with Hepatic Cirrhosis Following Administration of ACTH. Amer. J. Med. 13: 27 1952;
    CrossrefPubMedSearch in Google Scholar
  • 14 von Rokitansky K. Handbuch der Pathologischen Anatomie. Vol. 1-3 Braunmuller und Seidel: Wien; 1842-1846.
  • 15 Duguid J. B. Thrombosis as a Factor in the Pathogenesis of Coronary Atherosclerosis. J. Path. Bact. 58: 207 1946;
    CrossrefPubMedSearch in Google Scholar
  • 16 Astrup T. Connective Tissue, Thrombosis, and Atherosclerosis. Edited by Page I. H. New York and London: Academic Press; 223-236 1959
    Search in Google Scholar
  • 17 Schram A. C, Pilgeram L. O. Correlation of Activity Changes in Blood Coagulation Factors with Human Arteriosclerosis. Circulation 20: 991 1959;
    PubMedSearch in Google Scholar
  • 18 Pilgeram L. O. Relation of Plasma Fibrinogen Concentration Changes to Human Arteriosclerosis. J. appl. Physiol. 16: 660 1961;
    CrossrefPubMedSearch in Google Scholar