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Thromb Haemost 1961; 05(01): 108-111
DOI: 10.1055/s-0038-1654908
Originalarbeiten – Original Article – Travaux Originaux
Schattauer GmbH

Absence of Blood Clotting Substances from Synovial Fluid[*]

M. H Cho
1   Department of Physiology and Pharmacology, Department of Physiological Chemistry and Department of Anatomy, Wayne State University, College of Medicine, Detroit, Michigan
,
O. W Neuhaus
1   Department of Physiology and Pharmacology, Department of Physiological Chemistry and Department of Anatomy, Wayne State University, College of Medicine, Detroit, Michigan
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Publikationsdatum:
21. Juni 2018 (online)

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Summary

Analyses were performed on normal bovine synovial fluid for prothrombin, fibrinogen, Ac-globulin (factor V), autoprothrombin I (factor VII), tissue thromboplastin, and antithrombin. None of these active substances in blood clotting was found. The absence of these proteins, especially prothrombin (MW of 62 700), may be on the basis of selective permeability of the capillaries of the synovial membrane to certain plasma proteins.

* This study was supported by grant A-532 (C11) of the United States Public Health Service, and by the Michigan Chapter, Arthritis and Rheumatism Foundation.


 

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