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Thromb Haemost 1961; 05(02): 256-266
DOI: 10.1055/s-0038-1654923
Originalarbeiten – Original Article – Travaux Originaux
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Progressive Antithrombin and Fibrinogen The Antithrombin Time According to Innerfield and its Relation to Acute Pancreatitis

J. M Greep
1   Department of Surgery (Head: C. van Staveren), Department of Clinical Biochemistry (Head: Dr. B, Leijnse), Municipal Hospital Coolsingel Dijkzigt, Rotterdam. — Medical Department University Hospital (Director: Prof. Dr. J. Mulder), Leyden. — Medical Department University Hospital (Directors: Prof. Dr. L. A. Hulst and Prof. Dr. F. L. J. Jordan), Utrecht, Netherlands
,
E. A Loeliger
1   Department of Surgery (Head: C. van Staveren), Department of Clinical Biochemistry (Head: Dr. B, Leijnse), Municipal Hospital Coolsingel Dijkzigt, Rotterdam. — Medical Department University Hospital (Director: Prof. Dr. J. Mulder), Leyden. — Medical Department University Hospital (Directors: Prof. Dr. L. A. Hulst and Prof. Dr. F. L. J. Jordan), Utrecht, Netherlands
,
J Roos
1   Department of Surgery (Head: C. van Staveren), Department of Clinical Biochemistry (Head: Dr. B, Leijnse), Municipal Hospital Coolsingel Dijkzigt, Rotterdam. — Medical Department University Hospital (Director: Prof. Dr. J. Mulder), Leyden. — Medical Department University Hospital (Directors: Prof. Dr. L. A. Hulst and Prof. Dr. F. L. J. Jordan), Utrecht, Netherlands
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Publication Date:
21 June 2018 (online)

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Summary

Innerfield’s method of determining antithrombin III using plasma “defibrinated” by thrombin is submitted to criticsm. This method proves to involve insufficient defibrination: the higher the fibrinogen concentration of the plasma to be tested, the larger the fibrinogen remnant after “defibrination”. The residual fibrinogen interferes in the determinations of antithrombin III, as fibrin (antithrombin I) adsorbes thrombin; an increase in antithrombin III activity is suggested. This becomes manifest in all conditions associated with hyperfibrinogenaemia, including acute pancreatitis.

 

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