Studies on the Coagulation of the Blood in Patients Treated with Extra-Corporeal Circulation

S. I de Vries; S van Creveld; P Groen; E Müller; M Wettermark

doi:10.1055/s-0038-1654936

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1961; 05(03): 426-446
DOI: 10.1055/s-0038-1654936

Originalarbeiten – Original Article – Travaux Originaux

Schattauer GmbH

Studies on the Coagulation of the Blood in Patients Treated with Extra-Corporeal Circulation

Authors

S. I de Vries

¹Laboratory of Haematology and Blood Transfusion of the Wilhelmina-Gasthuis, Amsterdam, The Netherlands (Head: Dr. S. I. de Vries) and the Department of Paediatrics of the University of Amsterdam, The Netherlands (Head: Prof. Dr. S. van Creveld)
S van Creveld

¹Laboratory of Haematology and Blood Transfusion of the Wilhelmina-Gasthuis, Amsterdam, The Netherlands (Head: Dr. S. I. de Vries) and the Department of Paediatrics of the University of Amsterdam, The Netherlands (Head: Prof. Dr. S. van Creveld)
P Groen

¹Laboratory of Haematology and Blood Transfusion of the Wilhelmina-Gasthuis, Amsterdam, The Netherlands (Head: Dr. S. I. de Vries) and the Department of Paediatrics of the University of Amsterdam, The Netherlands (Head: Prof. Dr. S. van Creveld)
E Müller

¹Laboratory of Haematology and Blood Transfusion of the Wilhelmina-Gasthuis, Amsterdam, The Netherlands (Head: Dr. S. I. de Vries) and the Department of Paediatrics of the University of Amsterdam, The Netherlands (Head: Prof. Dr. S. van Creveld)
M Wettermark

¹Laboratory of Haematology and Blood Transfusion of the Wilhelmina-Gasthuis, Amsterdam, The Netherlands (Head: Dr. S. I. de Vries) and the Department of Paediatrics of the University of Amsterdam, The Netherlands (Head: Prof. Dr. S. van Creveld)

Abstract

Conclusions and summary

An extensive investigation of the coagulation mechanism was performed in 21 patients suffering from a congenital heart failure and exposed to surgical treatment with the aid of extra-corporeal circulation. The results have been discussed and suggestions given for the preoperative and postoperative mode of investigation in future. Only three factors may be considered a possible contraindication for the operation, namely

1. a persistent and marked thrombocytopenia,

2. fibrinogenopenia and

3. a high degree of fibrinolysis.

Before a final decision to operate is taken an attempt should be made to restore the impaired coagulation mechanism. The necessity of a preoperative analysis and a close cooperation between the surgeon and the coagulationist before, during and after the operation have been stressed.

Full Text

References

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