Inhibition of Fibrinolysis by Hyperlipemia^[*]

Summary

1. Parenteral injection of triton produced inhibition of fibrinolysis; this phenomenon correlated with hyperlipemia produced by the triton.

2. Triton induced hyperlipemia caused greater inhibition of fibrinolysis than did cholesterol feedings. It was suggested that this might be related to difference in cholesterol-phospholipid ratio.

3. Saturated fat emulsions produced a greater degree of fibrinolytic inhibition than did unsaturated fat preparations.

• References

• 1 O‘Brien J. R. Fat ingestion, blood coagulation, and atherosclerosis. Amer. J. Med. Sci 234: 373 1958;
• 2 Greig H. B. W. Inhibition of fibrinolysis by alimentary lipaemia. Lancet 02: 16 1956;
• 3 Scott R. F, Thomas W. A. Methods for comparing effects of various fats on fibrinolysis. Proc. Soc. exp. Biol. (N. Y) 96: 24 1957;
• 4 Rwaan H. C, Fadzean A. J. S Mac. Inhibition of fibrinolysis in vivo by feeding cholesterol. Nature (London) 179: 260 1957;
• 5 Kellner A, Correll J. W, Ladd A. T. Sustained hyperlipemia induced in rabbits by means of intravenously injected surface-active agents. J. Exp. Med 93: 373 1951;
• 6 Cliffton E. E, Cannamela D. A, Grossi C. In vivo studies of human plasmin-Intravenous injection indogs and rabbits. J. appl. Physiol 06: 143 1953;
• 7 Lee R. I, White P. D. A clinical study of the coagulation time of blood. Amer. J. med. Sci 145: 495 1913;
• 8 Downie G. R, Cliffton E. E. A method for assay of serum proteolytic activity. Proc. Soc. exp. Biol. (N. Y) 71: 138 1949;
• 9 Milestone H. J. A factor in normal human blood which participates in streptococcal fibrinolysis. J. Immunol 42: 109 1941;
• 10 Greig H. W. B, Runde I. A. Studies on the inhibition of fibrinolysis by lipides. Lancet. 2:. 1957
• 11 Kwaan H. G, Lo R, MacFadzean A. J. S. On the lysis of thrombi experimentally produced within veins. Brit. J. Haemat 04: 51 1958;