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Thromb Haemost 1963; 09(01): 120-125
DOI: 10.1055/s-0038-1654966
DOI: 10.1055/s-0038-1654966
Originalarbeiten — Original Articles — Travaux Originaux
An in vivo Trial of an Anti-Adhesive Drug
Further Information
Publication History
Publication Date:
21 June 2018 (online)
Summary
Ro-30837 given by mouth to seven people produced a variable but definite prolongation of the bleeding time and greater blood loss. This effect was probably due to a decrease in platelet adhesiveness.
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References
- 1 Borchgrevink C. F. A method for measuring platelet adhesiveness in vivo. Acta, med. scand. 168: 157-164 1960;
- 2 Bounameaux Y. Antihistaminiques de synthèse et retraction du caillot. Arch. int. Pharmacodyn 116: 252-254 1958;
- 3 Gough K. R. Capillary resistance to suction in hypertension. Brit. med. J. 01: 21-24 1962;
- 4 Kjaerheim A, Hovig T. The ultrastructure of haemostatic blood platelet plugs in rabbit mesenterium. Thrombos. Diathes. haemorrh. 07: 1-15 1962;
- 5 McDonald L, Edgill M. Action of heparin in ischaemic heart-disease. Lancet 01: 844-847 1961;
- 6 O’Brien J. R. The adhesiveness of native platelets and its prevention. J. clin. Path. 14: 140-149 1961;
- 7 O’Brien J. R. Platelet aggregation: Part I Some effects of the adenosine phosphates, thrombin, and cocaine upon platelet adhesiveness. Part II Some results from a new method of study. J. clin. Path. 15: 446-455 1962;
- 8 Poole J. C. F, French J. E. Thrombosis. J. Atheroscler. Res. 01: 251-282 1961;
- 9 Shimamoto J. Damages to “silicone-like property” of vascular endothelial cells and prevention by monoamino oxidase inhibitor, Nialamide. Asian Med. J. 03: 479-492 1960;