Influence of Plasmin on the Clotting and Anticlearing Activities of Platelets

Summary

Platelet factor 4 (antiheparin factor) is rapidly destroyed by plasmin. This phenomenon occurs as well in platelet suspensions as in their extracts.

Platelet factor 4 is more sensitive to the plasmin action than platelet factor 1. Platelet factor 3 is resistant to the plasmin action.

Platelet inhibitor of the clearing reaction is partially inactivated by plasmin.

• References

• 1 Alagille D, Soulier J. P. Action des enzymes proteolytiques sur le sang total in vitro. Sem. Hop. Paris. 32: 355 1956;
• 2 Ballerini G, La Paglia S. Ricerche sperimentali sull’attivita anti — “clearing factor” delle piastrine umane. Boll. Soc. ital. Biol. sper. 37: 289 1961;
• 3 Bierstedt P. Über die Beteiligung der Thrombozyten an der Fibrinolyse. Proc. of the sixth Congress of the European Society of Haematology. 483 Copenhagen; 1957 Karger, Basel.:
• 4 Deutsch E, Fischer M. Die Wirkung intravenös applizierter Streptokinase auf Fibrinolyse und Blutgerinnung. Thrombos. Diathes. haemorrh. 04: 482 1960;
• 5 Deutsch E, Kain W. Studies on Platelet Factor 4. International Symposium on Blood Platelets. Henry Ford Hospital. Little and Brown; Detroit: 1960
• 6 Duckert F, Flückiger P, Isenschmied H, Matter M, VogelMeng J, Koller F. A modification of the thromboplastin generation test. Acta haemat. (Basel) 12: 197 1954;
• 7 Greig H. B. W. The activation of lipoproteine and chylomicrone by streptokinase and the chylomicron clearing activity of streptokinase. Symposion Princeton on Thrombolytic Activity and Related Phenomena. 252 Schattauer; Stuttgart: 1961
• 8 Grosman M. J. The quantitative measurement of heparin induced lipemia clearing activity of plasma. J. Lab. clin. Med. 43: 445 1954;
• 9 Hjort P, Rapaport J. S, Owren P. A. Platelet accelerator identical to pro- accelerin and adsorbed from plasma? Scand. J. clin. Lab. Invest 07: 97 1955;
• 10 Holell C, Nestel P. J. Effect of blood platelets on heparin induced clearing reaction. Amer. J. Physiol. 199: 803 1960;
• 11 Holemans R, Gross R. Influence of blood platelets on fibrinolysis. Thrombos. Diathes. haemorrh. 06: 196 1961;
• 12 Konttinen Y. The effect of streptokinase on the plasma heparin thrombin time. Scand. J. clin. Lab. Invest 82: 14 1962;
• 13 Mitchell J. R. A. Inhibition of heparin clearing by platelets. Lancet 01: 169 1959;
• 14 Niewiarowski S, Latallo Z. Influence of plasmin on the first coagulation stage. Bull. Acad. pol. Sci. Cl. 2. 07: 219 1957;
• 15 Niewiarowski S, Kowalski E. Antithrombin formation during proteolysis of fibrinogen. Sixth Congress of the Europ. Soc. of Haemat. 158 Copenhagen..
• 16 Niewiarowski S, Latallo Z, Stachurska J. L’apparition d’un inhibiteur de la thromboplastinoformation au cours de la proteolyse du fibrinogène. Rev. Hémat. 14: 118 1959;
• 17 Niewiarowski S, Zywicka H, Latallo Z. Coagulation disorders in thrombocythemia. A study on seven cases. Thrombos. Diathes haemorrh. 07: 114 1962;
• 18 Norman P. S. Effect of urea and methylamine on plasmin. Proc. Soc. exp. Biol. (N. Y) 96: 709 1957;
• 19 Owren P. A. The coagulation of blood. Investigations on a new clotting factor. Acta med. scand. (suppl.) 1947; 194.