The Streptokinase Reactivity Test. I. Standardization

A Amery; H Maes; J Vermylen; M Verstraete

doi:10.1055/s-0038-1654972

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1963; 09(01): 175-188
DOI: 10.1055/s-0038-1654972

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

The Streptokinase Reactivity Test. I. Standardization

A Amery

¹University of Louvain, Department of Internal Medicine (Prof. J. Vandenbroucke), Laboratory of Coagulation and Proteolysis (Dr. M. Verstraete)

,

H Maes

¹University of Louvain, Department of Internal Medicine (Prof. J. Vandenbroucke), Laboratory of Coagulation and Proteolysis (Dr. M. Verstraete)

,

J Vermylen

¹University of Louvain, Department of Internal Medicine (Prof. J. Vandenbroucke), Laboratory of Coagulation and Proteolysis (Dr. M. Verstraete)

,

M Verstraete

¹University of Louvain, Department of Internal Medicine (Prof. J. Vandenbroucke), Laboratory of Coagulation and Proteolysis (Dr. M. Verstraete)

› Institutsangaben

Abstract

Summary

1. An attempt was made to standardize a method which determines the reactivity of a given blood sample with streptokinase (SKRT).

2. The nature of the thrombin and streptokinase used can greatly influence the test.

3. The 20 minutes value is less influenced by a number of parameters than other points on the streptokinase versus lysis time plot.

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Referenzen

References
1 Tillett W. S, Garner R. L. The fibrinolytic activity of hemolytic streptococci. J. exp. Med. 58: 485 1933;
2 Johnson A. J, Fletcher A. P, McCarty W. R, Tillett W. S. The intravascular use of streptokinase. Ann. N. Y. Acad. Sci. 68: 201 1957;
3 Fletcher A. Personal communication.
4 Deutsch E, Fischer M. Die Wirkung intravenös applizierter Streptokinase auf Fibrinolyse und Blutgerinnung. Thrombos. Diathes. haemorrh. 04: 482 1960;
5 Fischbacher W. Beitrag zur fibrinolytischen Therapie mit Streptokinase und Fibrinolysin. Thrombos. Diathes. haemorrh. 06: 547 1961;
6 Nilsson I. H, Olow B. Fibrinolysis induced by streptokinase in man. Acta chir. scand. 123: 247 1962;
7 Johnson A. J, McCarty W. R. The lysis of artificially induced intravascular clots in man by intravenous infusions of streptokinase. J. clin. Invest. 38: 1627 1959;
8 Amery A, Vermylen J, Maes H, Verstraete M. Enhancing the fibrinolytic activity in human blood by occlusions of blood vessels. Thrombos. Diathes. haemorrh. 07: 70 1962;
9 Fearnley G. R, Rivill R, Tweed J. M. Observation on the inactivation of fibrinolytic activity in shed blood. Clin. Sci. 02: 309 1952;
10 Devreker R, Vermylen C, Verstraete M. The purification of thrombin for use as a fibrinolytically inert reagent. Proc. Xth Coll. Protides of the Biological Fluids, Bruges 1962
11 Fearnley G. R, Tweed JMoore. Evidence of an active fibrinolytic enzyme in the plasma of normal people with observations on inhibition associated with the presence of calcium. Clin. Sci. 12: 81 1953;