The Inactivation of Plasma Thromboplastin by Heparin

Summary

Heparin at concentrations greater than 0.2 u/ml rapidly inactivated partially purified thromboplastin (plasma prothrombinase) prepared from pigs’ plasma in the thromboplastin generation test.

• References

• Biggs R, Douglas A. S, Macfarlane R. G. The action of thromboplastic substances. J. Physiol. 122: 554 1953;
• Cross M. J. Plasma prothrombinase. Nature (Lond). 195: 451 1962;
• Cross M. J. The separation of thromboplastin formed from pigs’ plasma in the thromboplastin generation test. Thrombos. Diathes. haemorrh. 08: 485 1962;
• MacMillan R. L, Brown K. W. G. Heparin and thromboplastin. J. Lab. clin. Med. 44: 378 1954;
• Shanberge J. N, Sarelis A, Regan E. E. The effect of heparin on plasma thromboplastin formation. J. Lab. clin. Med. 54: 501 1959;