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Thromb Haemost 1963; 09(02): 346-353
DOI: 10.1055/s-0038-1654989
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Activation of Hageman Factor (Factor XII) by Long-Chain Saturated Fatty Acids[*]

Paul Didisheim
1   Department of Medicine, University of Utah College of Medicine, Salt Lake City, Utah, USA
,
R Sougin Mibashan
1   Department of Medicine, University of Utah College of Medicine, Salt Lake City, Utah, USA
› Institutsangaben
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Publikationsdatum:
21. Juni 2018 (online)

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Summary

1. Long-chain saturated fatty acids accelerate the clotting of blood by activating Hageman factor (HF, factor XII). Their effect is proportional to their chain length.

2. The hypothesis is discussed that long-chain saturated fatty acids in the circulating blood of man may exert a similar effect, and may thus be one of the factors in the etiology of clinical thrombosis.

* Presented in part at meeting of Federation of American Societies for Experimental Biology, Atlantic City, N.J., USA, April 16, 1963.


 

  • References

  • 1 Connor W. E, Poole J. C. F. The effect of fatty acids on the formation of thrombi. Quart. J. exp. Physiol. 46: 1 1961;
    PubMedGoogle Scholar
  • 2 Connor W. E. The acceleration of thrombus formation by certain fatty acids. J. clin. Invest 41: 1199 1962;
    CrossrefPubMedGoogle Scholar
  • 3 Connor W. E, Hoak J. C, Warner E. D. Massive thrombosis produced by fatty acid infusion. Fed. Proc. 21: 60 1962;
    PubMedGoogle Scholar
  • 4 Didisheim P. The activation of Hageman factor by silicic acid. Fed. Proc. 18: 1 1959;
    PubMedGoogle Scholar
  • 5 Didisheim P. In: Wintrobe M. M. Clinical Hematology. 5th ed.. 298 Lea and Febiger; Philadelphia: 1961
  • 6 Didisheim P. Hageman factor deficiency (Hageman trait): case report and review of the literature. Arch, intern. Med. 110: 170 1962;
    CrossrefPubMedGoogle Scholar
  • 7 Duguid J. B. Thrombosis as a factor in the pathogenesis of coronary atherosclerosis. J. Path. Bact. 58: 207 1946;
    CrossrefPubMedGoogle Scholar
  • 8 Korsan-Bengtsen K, Ygge J. Mechanism of the clot-promoting effect of fatty acids and synthetic anionic detergents. Scand. J. clin. Lab. Invest 13: 594 1961;
    CrossrefPubMedGoogle Scholar
  • 9 Mertz E. T, Owen C. A. Imidazole buffer: its use in blood clotting studies. Proc. Soc. exp. Biol. (N. Y) 43: 204 1940;
    CrossrefPubMedGoogle Scholar
  • 10 O’Brien J. R. The effect of some fatty acids and phospholipids on blood coagulation. Brit. J. exp. Path. 38: 529 1957;
    PubMedGoogle Scholar
  • 11 Pilkington T. R. E. The effect of fatty acids and detergents on the calcium clotting time of human plasma. Clin. Sci. 16: 269 1957;
    PubMedGoogle Scholar
  • 12 Poole J. C. F. Effect of certain fatty acids on the coagulation of plasma in vitro. Brit. J. exp. Path. 36: 248 1955;
    PubMedGoogle Scholar
  • 13 Proc. of Internat. Conf. on Diet, Serum Lipids, and Atherosclerosis. Fed. Proc. (suppl.) 21: 11 1962;
    PubMedGoogle Scholar
  • 14 Rapaport S. I, Ames S. B, Mikkelsen S. Evidence that glass increases plasma PTA activity. J. Lab. clin. Med. 52: 624 1958;
    PubMedGoogle Scholar
  • 15 Ratnoff O. D, Rosenblum J. M. Role of Hageman factor in the initiation of clotting by glass. Evidence that glass frees Hageman factor from inhibition. Amer. J. Med. 25: 160 1958;
    PubMedGoogle Scholar