Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1962; 07(03): 480-490DOI: 10.1055/s-0038-1655397 Originalarbeiten — Original Articles — Travaux Originaux Schattauer GmbH The Mechanism of Platelet Aggregation in Relation to Hemostasis[*] R Käser-Glanzmann 1 Theodor Kocher Institute, University of Berne, Switzerland , E. F Lüscher 1 Theodor Kocher Institute, University of Berne, Switzerland › Author Affiliations Recommend Article Abstract PDF Download Buy Article Summary The finding that ADP induces the aggregation of human blood platelets is confirmed. Under the influence of thrombin platelets release enough. ADP to account for their mutual aggregation during viscous metamorphosis. Other nucleotides liberated under the same conditions are ATP and AMP. The nucleotides released from platelets during VM have been separated by chromatography and a molar ratio of ATP : ADP : AMP = 1 : 5 : 3 has been found. It is concluded that platelet aggregation by ADP in the course of the formation of the hemostatic plug is a self contained process normally independent of the presence of other blood cells. PDF (1612 kb) References References 1 Apitz K. Über Profibrin: V. Agglutination von Blutplättchen durch Profibrin. Z. ges. exp. Med 1939; 105: 89 2 Born G. V. R. Changes in the distribution of phosphorus in platelet-rich plasma. Biochem. J 1958; 68: 695 3 Bettex-Galland M, Lüscher E. F. Extraction of an actomyosin-like protein from human thrombocytes. Nature (Lond.) 1959; 184: 276 4 Bettex-Galland M, Lüscher E. F. Studies on the metabolism of human blood platelets in relation to clot retraction. Thromb. Diath. haem 1960; 4: 178 5 Bettex-Galland M, Lüscher E. F. Thrombosthenin — A contractile protein from thrombocytes. Its extraction from human blood platelets and some of its properties. Biochim. biophys. Acta (Amst.) 1961; 49: 536 6 Budtz- Olsen O. E. Clot retraction. Blackwell; Oxford: 1951 7 Cooney D. P, Blatt W. F, Jensen H. Studies on thrombopoiesis: I. Effect of a dialyzable spleen preparation on the thrombocyte level. Acta haemat. (Basel) 1961; 26: 317 8 Dausset J, Colin M. Technique de recherche des thromboagglutinines immuno-logiques. Influence du chauffage préalable de la suspension plaquettaire. Rev. franc. Étud. clin. biol 1958; 3: 60 9 Gaarder A. M, Laland S. The chemical nature of the platelet adhesiveness factor (factor R of Hellem). Proc. 8th Congr. Europ. Soc. Haematology, Vienna 1961, No.. Karger; Basel: 1962: 361 10 Gelin L. E. Studies in anemia of injury. Acta chir. Scand. Suppl 1956: 210 11 Hellem A. J. The adhesiveness of human blood platelets in vitro . Scand. J. clin. Lab. Invest 1960; 12 Suppl 51 12 Inglis J. A, Halliday J. W. Thromboplastic activity of red cells. Nature 1961; 191: 821 13 Lüscher E. F. Viscous metamorphosis of blood platelets and clot retraction. Vox sang 1956; 1: 133 14 Lüscher E. F. Verh. ber. Schweiz. Chem. Ges., Chimia 1961; 15: 570 15 Øllgaard E. (a) Clot retraction as a quantitative test of the function and agglutinability of the blood platelets. Acta haemat. (Basel) 1951; 6: 221 285b Macroscopic studies on platelet aggregation — Nature of an aggregating factor in red blood cells and platelets. Thromb. Diath. Haem 1961; 6: 86 16 Parmeggiani A. Elektronenoptische Beobachtungen an menschlichen Blutplättchen während der viskosen Metamorphose. Thromb. Diath. haem 1961; 6: 517 17 Randerath K. Dünnschichtchromatographie an Ionenaustauscherschichten. Angew. Chem 1961; 73: 674 18 Szeinberg A, Moscowich-Gaffni D. Clot retraction activity of platelets. Acta haemat. (Basel) 1959; 21: 250 19 Waller H. D, Löhr G. W, Grignani F, Gross K. Über den Energiestoffwechsel normaler menschlicher Thrombozyten. Thromb. Diath. haem 1959; 3: 520
