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Thromb Haemost 1962; 08(02): 276-285
DOI: 10.1055/s-0038-1655427
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Studies on the In Vivo Behavior of Blood Coagulation Product I in Rats[*]

Theodore H Spaet
1   Department of Hematology, Laboratory Division, Montefiore Hospital, New York
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14. Mai 2019 (online)

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Summary

Evidence is presented in rats that the liver is involved in clearance from the circulation of the coagulant intermediate, product I. Although product I injected into the general circulation failed to elicit the defibrination syndrome, similar injections accompanied by ligation of the hepatic blood supply were followed by a significant drop in plasma fibrinogen. Product I was largely inactivated following perfusion through the liver, but addition of antiheparin drugs to the perfusate prevented this inactivation. No anticoagulant activity could be demonstrated in perfused material. Perfusion through the liver of product I precursors demonstrated inactivation of factor IX but no effect on factors V, VII, VIII, or X.

* This study was supported by Grant # HE-05415-02 of the National Heart Institute, National Institutes of Health, United States Public Health Service.


 

  • References

  • 1 Spaet T. H, Kropatkin M. Effect of intravenous blood thromboplastin intermediates on clotting in rats.. Amer. J. Physiol. 1958; 195: 77
    PubMedSuche in Google Scholar
  • 2 Spaet T. H, Horowitz H. I, Zucker-Franklin D, Cintron J, Biezenski J. J. Reticuloendothelial clearance of blood thromboplastin by rats.. Blood 1961; 17: 196
    CrossrefPubMedSuche in Google Scholar
  • 3 Bergsagel D. E, Nougie C. Intermediate stages in the formation of blood thromboplastin.. Brit. J. Haemat. 1956; 2: 113
    CrossrefPubMedSuche in Google Scholar
  • 4 Spaet T. H, Cintron J. Clearance of blood coagulation product I in rabbits.. Proc. Soc. exper. Biol. 1960; 104: 498
    CrossrefPubMedSuche in Google Scholar
  • 5 Horowitz H. I, Spaet T. H. Generation of product I and its interaction with platelets and phospholipids.. J. appl. Physiol. 1961; 16: 112
    CrossrefPubMedSuche in Google Scholar
  • 6 Nougie C, Barrow E. M, Graham J. B. Stuart Clotting Defect. I. Separation of an hereditary hemorrhagic state from the heterogenous group heretofore called “stable factor” (SPCA, proconvertin, factor VII) deficiency.. J. clin. Invest. 1957; 36: 485
    CrossrefPubMedSuche in Google Scholar
  • 7 Kudrjashov B. A. Interrelations between the blood coagulation system and the physiological anticoagulating system.. Nature (London) 1959; 184: 444
    PubMedSuche in Google Scholar
  • 8 Kudrjashov B. A. On the physiological anticoagulating system.. Thrombos. Diathes. haemorrh. 1961; 6: 371
    PubMedSuche in Google Scholar
  • 9 Javid J. Unpublished observations..
    PubMed
  • 10 Zucker-Franklin D, Spaet T. H. The nature and purification of product I.. In preparation.
    PubMed